Detailed information of TA system TA101340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4204442..4205992
• Replicon: chromosome
• Accession: NZ_CP028487
• Organism: Yersinia massiliensis strain GTA

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0T9TNV2
• Locus tag: DA391_RS19440
• Protein ID: WP_050080816.1
• Coordinates: 4204442..4205737 (-)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: DA391_RS19445
• Protein ID: WP_050080817.1
• Coordinates: 4205741..4205992 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA391_RS19415	4200212..4201213	+	1002	WP_108088085.1	autoinducer 2 ABC transporter permease LsrD	-
DA391_RS19420	4201294..4202313	+	1020	WP_019211214.1	autoinducer 2 ABC transporter substrate-binding protein LsrB	-
DA391_RS19425	4202369..4203244	+	876	WP_019211215.1	3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase	-
DA391_RS19430	4203265..4203555	+	291	WP_019211216.1	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase	-
DA391_RS19435	4203796..4204278	+	483	WP_050080815.1	DUF2501 domain-containing protein	-
DA391_RS19440	4204442..4205737	-	1296	WP_050080816.1	type II toxin-antitoxin system HipA family toxin	Toxin
DA391_RS19445	4205741..4205992	-	252	WP_050080817.1	helix-turn-helix domain-containing protein	Antitoxin
DA391_RS19450	4206109..4206945	+	837	WP_050286206.1	3'-kinase	-
DA391_RS19455	4207030..4208766	+	1737	WP_050080819.1	SulP family inorganic anion transporter	-
DA391_RS19460	4209187..4209792	+	606	WP_050872449.1	response regulator transcription factor	-
DA391_RS19465	4209991..4210587	-	597	WP_050080822.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 48487.86 Da
• Isoelectric Point: 6.5940

>T101340 WP_050080816.1 NZ_CP028487:c4205737-4204442 [Yersinia massiliensis]
MEKLTLALNGIVVGTLEKAAGGEISFFYHDSWLERSGARAISLSLPLQTVKFRGEVVYNFFDNLLPDSESIRSRIQARFQ
TPTKQPFDLLSQIGSDCVGAIQLYPEGRQINSVTEIHATPLNDNEIEKLLLGYKEAPLGMEADIDDFRISLAGAQEKTAL
LWYQNQWHRPEGSTPTSHILKLPIGYIAANGIDLSESVENEWLCLKIAEEFGLPVAYSEIKYFGKQKALVVERFDRRWSP
NNSWLMRLPQEDFCQVLGVAPALKYESDGGPGIADAMKLLLGSQQAIQDRDIFFKSQILFWMLAAIDGHAKNFSVFIELD
SAFRMTPIYDVMSAFPLMHPRGIPAKKAKMAMALLGRNRHFHWSTILPRHFISTAKQVNYPEDNVVQLMAEMKEKTEQVI
AAVKAVLPQGFPEKISEPIFSGLRRQSAKLP

Nucleotide

• Length: 1296 bp

>T101340 NZ_CP028487:c4205737-4204442 [Yersinia massiliensis]
ATGGAAAAGTTAACCCTTGCATTAAACGGCATCGTAGTTGGTACCTTGGAGAAGGCTGCCGGTGGTGAAATCTCTTTTTT
CTATCATGATAGCTGGCTTGAACGCAGTGGAGCACGTGCGATTTCTCTGTCGTTACCCCTACAAACGGTGAAATTCCGTG
GGGAGGTTGTTTATAATTTTTTTGATAACCTTCTGCCTGACAGTGAATCTATTCGCAGCCGTATTCAAGCGCGTTTTCAA
ACACCAACAAAGCAACCTTTTGATTTACTCTCCCAAATAGGGAGTGATTGCGTAGGGGCAATTCAATTATACCCAGAAGG
CCGGCAAATAAATTCTGTCACCGAGATCCATGCAACGCCTTTAAATGACAATGAGATAGAAAAATTACTCTTAGGGTATA
AGGAGGCGCCTTTGGGCATGGAGGCCGATATTGATGATTTCCGTATTTCTTTGGCTGGGGCACAAGAGAAAACAGCCTTA
CTGTGGTATCAGAATCAATGGCATCGGCCAGAAGGGAGTACACCAACGAGTCATATTCTTAAATTGCCTATAGGCTATAT
AGCCGCTAATGGTATTGATTTAAGTGAAAGTGTCGAGAATGAATGGTTGTGCTTAAAGATTGCTGAAGAATTTGGTCTAC
CTGTCGCGTATTCAGAAATAAAATATTTTGGTAAGCAAAAGGCATTAGTTGTTGAGCGGTTCGATCGCCGCTGGAGCCCT
AATAATAGTTGGTTGATGCGTTTACCGCAGGAGGATTTTTGTCAGGTCTTAGGTGTAGCACCTGCACTCAAATATGAATC
TGATGGTGGTCCTGGGATTGCAGATGCGATGAAACTATTACTCGGTTCTCAGCAAGCGATTCAGGATCGGGATATTTTTT
TTAAAAGTCAGATACTTTTCTGGATGTTAGCCGCGATTGACGGGCACGCGAAGAATTTTAGTGTGTTTATTGAATTGGAT
AGCGCATTTCGTATGACACCCATTTACGATGTGATGTCTGCATTTCCACTCATGCACCCACGAGGAATACCGGCTAAAAA
AGCAAAAATGGCCATGGCATTACTTGGACGTAATCGGCATTTTCACTGGAGTACTATTTTACCTCGGCACTTCATTTCAA
CCGCGAAACAGGTGAATTATCCCGAAGATAATGTTGTGCAATTAATGGCTGAAATGAAAGAAAAAACCGAACAAGTGATA
GCTGCGGTGAAGGCGGTTCTACCACAGGGCTTTCCCGAAAAAATCAGTGAGCCTATTTTCTCTGGTTTAAGGCGGCAGTC
GGCGAAACTGCCCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9584.94 Da
• Isoelectric Point: 10.4866

>AT101340 WP_050080817.1 NZ_CP028487:c4205992-4205741 [Yersinia massiliensis]
MKITSAAMLANTLRNERKKSKLTQRKTAETVGLKQSTVSEFENHPDGTKLDTLFKLLAALDLELQVRPRNRNIKDNTTWD
QEW

Nucleotide

• Length: 252 bp

>AT101340 NZ_CP028487:c4205992-4205741 [Yersinia massiliensis]
ATGAAAATTACCTCTGCTGCAATGTTGGCAAATACACTACGGAATGAACGCAAAAAAAGTAAGCTGACTCAGCGAAAAAC
AGCCGAGACAGTCGGTTTGAAGCAATCAACAGTATCAGAGTTTGAAAACCATCCTGATGGTACCAAATTAGACACGCTGT
TTAAGTTATTGGCAGCACTGGATTTAGAGCTACAGGTTAGGCCAAGGAACCGCAATATTAAGGATAATACAACCTGGGAT
CAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0T9TNV2