Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | NpoTA/- |
| Location | 263071..264248 | Replicon | chromosome |
| Accession | CP012111 | ||
| Organism | Acetobacter pasteurianus strain Ab3 | ||
Toxin (Protein)
| Gene name | NpoT | Uniprot ID | - |
| Locus tag | DB34_01190 | Protein ID | AKR47726.1 |
| Coordinates | 263071..263373 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | NpoA | Uniprot ID | - |
| Locus tag | DB34_01195 | Protein ID | AKR47727.1 |
| Coordinates | 263394..264248 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DB34_01180 | 258972..260600 | - | 1629 | AKR47724.1 | glycogen synthase | - |
| DB34_01185 | 260812..262932 | + | 2121 | AKR47725.1 | glycogen debranching enzyme | - |
| DB34_01190 | 263071..263373 | + | 303 | AKR47726.1 | plasmid stabilization protein | Toxin |
| DB34_01195 | 263394..264248 | + | 855 | AKR47727.1 | NAD(P)-dependent oxidoreductase | Antitoxin |
| DB34_01200 | 264329..266116 | - | 1788 | AKR49802.1 | thiamine pyrophosphate-binding protein | - |
| DB34_01205 | 266201..267661 | - | 1461 | AKR47728.1 | monooxygenase | - |
| DB34_01210 | 267824..268489 | + | 666 | AKR47729.1 | electron transporter SenC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 254571..268489 | 13918 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 10770.76 Da Isoelectric Point: 10.9433
>T10134 AKR47726.1 CP012111:263071-263373 [Acetobacter pasteurianus]
MPRGDKSAYTDTQKRQAEHIEKSYEQHGVSEKEAERRAWATVNKETGGGKKSGSGRGHPVTHAPSRKGGKAGGEASAHRT
AEERSASARKAAQTRKKNST
MPRGDKSAYTDTQKRQAEHIEKSYEQHGVSEKEAERRAWATVNKETGGGKKSGSGRGHPVTHAPSRKGGKAGGEASAHRT
AEERSASARKAAQTRKKNST
Download Length: 303 bp
>T10134 CP012111:263071-263373 [Acetobacter pasteurianus]
ATGCCTCGTGGTGACAAATCTGCTTACACAGACACGCAAAAACGACAAGCTGAACATATCGAAAAAAGCTATGAGCAACA
TGGTGTCAGTGAAAAGGAAGCTGAACGCCGGGCTTGGGCTACGGTTAACAAAGAAACCGGTGGTGGCAAGAAAAGTGGAT
CAGGAAGAGGCCATCCCGTAACACATGCCCCCTCACGCAAAGGTGGCAAAGCGGGTGGAGAGGCCTCCGCCCACCGGACG
GCAGAAGAGCGCTCTGCCTCTGCACGAAAAGCCGCTCAAACTCGCAAGAAAAATTCAACATAA
ATGCCTCGTGGTGACAAATCTGCTTACACAGACACGCAAAAACGACAAGCTGAACATATCGAAAAAAGCTATGAGCAACA
TGGTGTCAGTGAAAAGGAAGCTGAACGCCGGGCTTGGGCTACGGTTAACAAAGAAACCGGTGGTGGCAAGAAAAGTGGAT
CAGGAAGAGGCCATCCCGTAACACATGCCCCCTCACGCAAAGGTGGCAAAGCGGGTGGAGAGGCCTCCGCCCACCGGACG
GCAGAAGAGCGCTCTGCCTCTGCACGAAAAGCCGCTCAAACTCGCAAGAAAAATTCAACATAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 30493.66 Da Isoelectric Point: 5.6404
>AT10134 AKR47727.1 CP012111:263394-264248 [Acetobacter pasteurianus]
MMVHEERIPPQHQAVPGETDKMNPIPDHGEESYRGSGKLSGKVALITGADSGIGRAVAIAFAREGADIAIAYYTEDKDAQ
TTAEWVEKAGRRAILLPGDIRLRSHCNDIIKRTIDAFGNLNILVNNAAHQKSIKDLSEIDEEELDTTFRTNFYGMFFLCQ
AALPYLSSGASIINTTSINAVQPSPHLPVYAATKAAISNFTAGLAQMLGEKNIRVNAVAPGPVWTPLIPSTMPQEEIAKF
GKNTPLGRPAQPAELASAYVMFASDEASYTTGAVLPVTGGRPML
MMVHEERIPPQHQAVPGETDKMNPIPDHGEESYRGSGKLSGKVALITGADSGIGRAVAIAFAREGADIAIAYYTEDKDAQ
TTAEWVEKAGRRAILLPGDIRLRSHCNDIIKRTIDAFGNLNILVNNAAHQKSIKDLSEIDEEELDTTFRTNFYGMFFLCQ
AALPYLSSGASIINTTSINAVQPSPHLPVYAATKAAISNFTAGLAQMLGEKNIRVNAVAPGPVWTPLIPSTMPQEEIAKF
GKNTPLGRPAQPAELASAYVMFASDEASYTTGAVLPVTGGRPML
Download Length: 855 bp
>AT10134 CP012111:263394-264248 [Acetobacter pasteurianus]
ATGATGGTACATGAAGAAAGAATTCCCCCTCAACATCAGGCAGTTCCTGGTGAAACAGACAAAATGAATCCTATCCCCGA
TCATGGGGAAGAAAGTTATCGAGGCTCTGGAAAGCTTTCTGGCAAAGTTGCTTTGATAACAGGAGCAGATTCTGGAATAG
GTCGAGCAGTTGCCATTGCTTTTGCACGTGAAGGTGCAGATATTGCAATTGCTTATTATACAGAAGACAAAGATGCTCAG
ACAACAGCTGAATGGGTAGAAAAAGCCGGGCGCCGCGCAATCTTACTCCCGGGAGATATTCGATTACGCTCACATTGTAA
CGATATTATAAAACGCACCATAGATGCATTCGGAAATCTCAATATTTTGGTAAACAATGCGGCTCATCAAAAATCTATTA
AAGATCTTTCCGAAATTGATGAAGAAGAGCTTGATACTACGTTCCGTACAAATTTTTACGGTATGTTTTTTCTCTGTCAG
GCAGCTTTGCCATATTTAAGCAGTGGGGCTTCGATTATTAACACAACTTCGATCAACGCTGTACAACCATCCCCGCATTT
GCCTGTCTATGCTGCCACAAAAGCAGCTATTTCCAATTTTACAGCGGGCCTTGCCCAAATGTTGGGAGAAAAAAATATTC
GTGTAAATGCTGTTGCACCTGGTCCAGTTTGGACACCACTTATTCCATCAACAATGCCGCAGGAAGAGATTGCCAAATTT
GGTAAAAACACTCCTCTTGGCCGGCCAGCACAACCAGCAGAACTCGCTTCTGCCTACGTCATGTTCGCTTCAGATGAAGC
AAGTTACACAACAGGCGCTGTTCTTCCCGTAACTGGCGGAAGACCTATGCTTTAG
ATGATGGTACATGAAGAAAGAATTCCCCCTCAACATCAGGCAGTTCCTGGTGAAACAGACAAAATGAATCCTATCCCCGA
TCATGGGGAAGAAAGTTATCGAGGCTCTGGAAAGCTTTCTGGCAAAGTTGCTTTGATAACAGGAGCAGATTCTGGAATAG
GTCGAGCAGTTGCCATTGCTTTTGCACGTGAAGGTGCAGATATTGCAATTGCTTATTATACAGAAGACAAAGATGCTCAG
ACAACAGCTGAATGGGTAGAAAAAGCCGGGCGCCGCGCAATCTTACTCCCGGGAGATATTCGATTACGCTCACATTGTAA
CGATATTATAAAACGCACCATAGATGCATTCGGAAATCTCAATATTTTGGTAAACAATGCGGCTCATCAAAAATCTATTA
AAGATCTTTCCGAAATTGATGAAGAAGAGCTTGATACTACGTTCCGTACAAATTTTTACGGTATGTTTTTTCTCTGTCAG
GCAGCTTTGCCATATTTAAGCAGTGGGGCTTCGATTATTAACACAACTTCGATCAACGCTGTACAACCATCCCCGCATTT
GCCTGTCTATGCTGCCACAAAAGCAGCTATTTCCAATTTTACAGCGGGCCTTGCCCAAATGTTGGGAGAAAAAAATATTC
GTGTAAATGCTGTTGCACCTGGTCCAGTTTGGACACCACTTATTCCATCAACAATGCCGCAGGAAGAGATTGCCAAATTT
GGTAAAAACACTCCTCTTGGCCGGCCAGCACAACCAGCAGAACTCGCTTCTGCCTACGTCATGTTCGCTTCAGATGAAGC
AAGTTACACAACAGGCGCTGTTCTTCCCGTAACTGGCGGAAGACCTATGCTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Kai Xia et al. (2019) Characterization and comparative analysis of toxin-antitoxin systems in Acetobacter pasteurianus. Journal of Industrial Microbiology & Biotechnology 46(6):869-882. [PubMed:30805740]