Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3590565..3591184 Replicon chromosome
Accession NZ_CP028487
Organism Yersinia massiliensis strain GTA

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag DA391_RS16815 Protein ID WP_002208622.1
Coordinates 3590981..3591184 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9UMX9
Locus tag DA391_RS16810 Protein ID WP_019212878.1
Coordinates 3590565..3590933 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA391_RS16780 3586267..3586527 + 261 WP_050082629.1 type B 50S ribosomal protein L31 -
DA391_RS16785 3586543..3586686 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
DA391_RS16790 3586769..3587647 - 879 WP_108088009.1 metal ABC transporter substrate-binding protein -
DA391_RS16795 3587676..3588533 - 858 WP_050082626.1 metal ABC transporter permease -
DA391_RS16800 3588530..3589267 - 738 WP_057644342.1 ABC transporter ATP-binding protein -
DA391_RS16805 3590053..3590406 + 354 WP_050286524.1 hypothetical protein -
DA391_RS16810 3590565..3590933 + 369 WP_019212878.1 Hha toxicity modulator TomB Antitoxin
DA391_RS16815 3590981..3591184 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
DA391_RS16820 3591897..3594407 - 2511 WP_108088297.1 autotransporter outer membrane beta-barrel domain-containing protein -
DA391_RS16825 3595096..3595518 + 423 WP_050082618.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T101339 WP_002208622.1 NZ_CP028487:3590981-3591184 [Yersinia massiliensis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T101339 NZ_CP028487:3590981-3591184 [Yersinia massiliensis]
ATGACTAAAACTGACTACCTGATGCGTTTAAGAAAGTGTACGACTATTGACACGCTTGAGCGTGTAATTGAAAAAAATAA
ATATGAACTTTCTGACGATGAGTTGGAGTTATTCTACTCAGCAGCCGATCATCGCTTAGCTGAGCTCACAATGAATAAGC
TTTATGATAAAATTCCACCTACAGTTTGGCAGCATGTAAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14204.96 Da        Isoelectric Point: 4.4314

>AT101339 WP_019212878.1 NZ_CP028487:3590565-3590933 [Yersinia massiliensis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTAAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKS

Download         Length: 369 bp

>AT101339 NZ_CP028487:3590565-3590933 [Yersinia massiliensis]
ATGGATGAGTACTCGCCAAAAAGGCATGATATTGCCCAACTGAAGTTTCTCTGTGAGAGTTTGTATGATGAAGGTATTGC
TACGCTCGGCGATAGCCATCATGGGTGGGTGAACGACCCCACAGCAGCTGTCAATCTGCAACTTAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCAGACGACGGCGACCTATCAGAGCTAGTGGAAGAATATTTA
GACGATACTTATACTCTGTTTAGTAGTTACGGGATCAACGATCCCGAATTGCGTCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACGCTGATGAAAAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UMX9

References