Detailed information of TA system TA101337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2500411..2501380
• Replicon: chromosome
• Accession: NZ_CP028487
• Organism: Yersinia massiliensis strain GTA

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9TXD8
• Locus tag: DA391_RS11650
• Protein ID: WP_050081128.1
• Coordinates: 2500922..2501380 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9TWM5
• Locus tag: DA391_RS11645
• Protein ID: WP_050081127.1
• Coordinates: 2500411..2500857 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA391_RS11625	2496023..2496739	+	717	WP_098904506.1	murein tripeptide amidase MpaA	-
DA391_RS11630	2496744..2497715	-	972	WP_057649458.1	L-Ala-D/L-Glu epimerase	-
DA391_RS11635	2497870..2498373	+	504	WP_019209936.1	thiol peroxidase	-
DA391_RS11640	2498515..2500092	-	1578	WP_050081126.1	transcriptional regulator TyrR	-
DA391_RS11645	2500411..2500857	+	447	WP_050081127.1	DUF2384 domain-containing protein	Antitoxin
DA391_RS11650	2500922..2501380	+	459	WP_050081128.1	RES family NAD+ phosphorylase	Toxin
DA391_RS11655	2501407..2502468	-	1062	WP_050081129.1	YcjF family protein	-
DA391_RS11660	2502465..2503862	-	1398	WP_050081130.1	YcjX family protein	-
DA391_RS11665	2503843..2504082	-	240	WP_019209930.1	phage shock protein PspD	-
DA391_RS11670	2504140..2504514	-	375	WP_050285589.1	envelope stress response membrane protein PspC	-
DA391_RS11675	2504514..2504741	-	228	WP_050285588.1	envelope stress response membrane protein PspB	-
DA391_RS11680	2504859..2505524	-	666	WP_050285587.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17297.66 Da
• Isoelectric Point: 5.1578

>T101337 WP_050081128.1 NZ_CP028487:2500922-2501380 [Yersinia massiliensis]
MKLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHSAIYLASSVSLAMLETLAHIQDSSTLSEFELFQIEIDDNNIMLLHPT
DWPIDWRNDPAPATTMDVGTEWLESESSVGLLVPSTLVPSENNMLVNPRHKDFQAYLNSVKPLPFSFDPRLK

Nucleotide

• Length: 459 bp

>T101337 NZ_CP028487:2500922-2501380 [Yersinia massiliensis]
ATGAAGCTTTACCGTATTGTGATGCGCCGTTATTTGGCCTCAGCATGGACGGGTTATGGCGCTGAAATCTATGGTGGCCG
CTGGAACCATAAGGGCCACTCCGCGATTTATTTAGCCAGCAGCGTATCGTTAGCGATGTTAGAAACGTTGGCGCATATTC
AAGACAGTTCAACCCTCAGTGAGTTTGAGCTATTTCAAATTGAAATTGATGACAACAATATTATGCTGTTGCATCCAACC
GATTGGCCCATCGACTGGCGCAACGATCCAGCTCCCGCCACGACAATGGATGTTGGCACCGAGTGGTTAGAATCAGAATC
CTCCGTTGGATTACTGGTGCCCTCCACTCTGGTGCCTTCAGAAAATAATATGTTGGTCAATCCACGCCACAAAGACTTTC
AGGCTTACTTGAACAGTGTCAAACCGCTTCCGTTCTCTTTTGATCCGCGGCTGAAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16233.65 Da
• Isoelectric Point: 9.1260

>AT101337 WP_050081127.1 NZ_CP028487:2500411-2500857 [Yersinia massiliensis]
MRAYHPTPTAKTGALWREIGLPASRGTILVDSIKLGFSVDVIDSIHLWAAIPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT101337 NZ_CP028487:2500411-2500857 [Yersinia massiliensis]
ATGAGAGCATATCACCCCACCCCAACAGCCAAAACAGGCGCGCTCTGGCGTGAAATAGGTCTACCCGCCAGCCGCGGCAC
CATCTTGGTCGACAGCATAAAGTTAGGGTTTTCGGTTGACGTTATCGATAGCATTCACCTTTGGGCTGCGATACCTAAAT
CTGAGATTCTACGCGCAACAGGGATCCCCAGCCGTAGCCTGACCCGTCGGCGCACTCATGATGGCCGTTTCACGCCGGAA
GAGAGTGAGCGAATTGCGCGTTTTGTACGCGTCATGGATGCTGCCGTTGATCTTTTTGGTGGCGATAAAGGCAAGGCTAT
CACTTGGATGTCAACACCGATTAAAGGTTTGGGCCACCGCAGTCCTGATTCATTATTAGAGACAGAAACCGGCGCCTTAG
AAGTCTGTGACTTAATTGGGCGGCTGGAGCACGGCGTATTCTCTTAA

Structures

Toxin

• AlphaFold DB: A0A0T9TXD8

Antitoxin

• AlphaFold DB: A0A0T9TWM5