Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 107828..108438 Replicon chromosome
Accession NZ_CP028487
Organism Yersinia massiliensis strain GTA

Toxin (Protein)


Gene name doc Uniprot ID A0A0T9UYD5
Locus tag DA391_RS00450 Protein ID WP_050083383.1
Coordinates 107828..108220 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0T9UY83
Locus tag DA391_RS00455 Protein ID WP_049610050.1
Coordinates 108217..108438 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA391_RS00425 103050..103235 + 186 WP_049610039.1 hypothetical protein -
DA391_RS00430 103441..104589 + 1149 WP_050083387.1 pectate lyase -
DA391_RS00435 104668..104847 - 180 Protein_82 FKBP-type peptidyl-prolyl cis-trans isomerase -
DA391_RS00440 104878..106488 - 1611 WP_108087239.1 FAD-NAD(P)-binding protein -
DA391_RS00445 107130..107750 - 621 WP_206186971.1 isochorismatase family protein -
DA391_RS00450 107828..108220 - 393 WP_050083383.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DA391_RS00455 108217..108438 - 222 WP_049610050.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DA391_RS00460 108688..109551 - 864 WP_050287365.1 YicC family protein -
DA391_RS00465 109681..110397 + 717 WP_004705100.1 ribonuclease PH -
DA391_RS00470 110509..111156 + 648 WP_108087240.1 orotate phosphoribosyltransferase -
DA391_RS00475 111640..112935 + 1296 WP_108087241.1 dicarboxylate/amino acid:cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14813.78 Da        Isoelectric Point: 6.9895

>T101325 WP_050083383.1 NZ_CP028487:c108220-107828 [Yersinia massiliensis]
MMWISAQEVIAFHDRILQRLPGVTGIPDPGRAEALIYRVQNRTHYEGVTDVFELGATYWVAIARGHIFNDGNKRTAFFVT
MAFLYRNGIRIRDTDNSLENLTVAAATGEKTVDQLSQHLRDLVEHTNQIR

Download         Length: 393 bp

>T101325 NZ_CP028487:c108220-107828 [Yersinia massiliensis]
ATGATGTGGATCAGCGCTCAGGAGGTTATCGCTTTTCATGACCGCATATTGCAACGGCTCCCCGGCGTTACTGGTATACC
CGATCCCGGCAGGGCCGAAGCACTCATTTATCGGGTGCAAAACCGAACACATTATGAAGGCGTGACAGATGTTTTTGAAC
TCGGCGCCACCTACTGGGTCGCTATCGCTCGTGGACACATTTTTAACGATGGTAATAAACGTACTGCGTTTTTCGTTACC
ATGGCTTTCCTCTATCGCAATGGCATCAGGATCCGTGATACCGATAATTCGCTGGAAAATTTAACGGTAGCGGCAGCGAC
AGGTGAGAAAACCGTTGACCAGTTATCGCAACATCTACGAGATTTGGTGGAACATACTAACCAAATTCGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.99 Da        Isoelectric Point: 5.5675

>AT101325 WP_049610050.1 NZ_CP028487:c108438-108217 [Yersinia massiliensis]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFETYQNAKLDAEFDVIMQRHGHTVEALTNR

Download         Length: 222 bp

>AT101325 NZ_CP028487:c108438-108217 [Yersinia massiliensis]
ATGCGTACTTACACTTCAACCCAAGCTCGAGCAAATATTTCAGAAGTATTGGATGCGGCCACTCATGGCGAACCTGTTGA
AATCACCCGCCGAGACGGTAGCTCGGCAGTGGTTATCAGTAAGGCTGAATTTGAGACATACCAAAACGCTAAGCTTGATG
CAGAGTTCGATGTCATTATGCAACGTCATGGTCATACTGTAGAGGCGCTGACAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UYD5

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UY83

References