Detailed information of TA system TA101324

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 89265..89953
• Replicon: chromosome
• Accession: NZ_CP028487
• Organism: Yersinia massiliensis strain GTA

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: DA391_RS00400
• Protein ID: WP_108087236.1
• Coordinates: 89633..89953 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: DA391_RS00395
• Protein ID: WP_108087235.1
• Coordinates: 89265..89582 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA391_RS00370	85669..86103	+	435	WP_108087230.1	hypothetical protein	-
DA391_RS00375	86233..87099	+	867	WP_108087231.1	hypothetical protein	-
DA391_RS24310	87116..87289	+	174	WP_167398153.1	hypothetical protein	-
DA391_RS00380	87321..87809	+	489	WP_108087232.1	hypothetical protein	-
DA391_RS00385	87898..88716	+	819	WP_108087233.1	DUF945 domain-containing protein	-
DA391_RS00390	88782..89252	+	471	WP_108087234.1	DNA repair protein RadC	-
DA391_RS00395	89265..89582	+	318	WP_108087235.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DA391_RS00400	89633..89953	+	321	WP_108087236.1	TA system toxin CbtA family protein	Toxin
DA391_RS00405	90224..90472	-	249	WP_050873955.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (7-104)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12137.81 Da
• Isoelectric Point: 4.5494

>T101324 WP_108087236.1 NZ_CP028487:89633-89953 [Yersinia massiliensis]
MQISTAPITAPVPSRVSPVKVWQQLLTYLFEHHYGLTINEAPFSDDTAILEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWLTPLDVQRAQFNLGLMRS

Nucleotide

• Length: 321 bp

>T101324 NZ_CP028487:89633-89953 [Yersinia massiliensis]
ATGCAAATCTCAACCGCTCCGATCACAGCGCCGGTACCGTCACGCGTGTCCCCTGTCAAAGTATGGCAACAATTGTTAAC
GTACCTTTTTGAGCATCATTACGGCCTCACAATCAATGAAGCGCCGTTCAGTGACGATACGGCGATTCTGGAACACATAG
AGGCCGGGGTGAATCTTACTGATGCCGTTAACTTCCTTGTGGAACGATTCGAACTTGTTCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGCTAACACCTTTGGATGTTCAACGAGCACAGTTCAACCTTGGCTTGATGCGTTCATA
A

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11758.43 Da
• Isoelectric Point: 6.4677

>AT101324 WP_108087235.1 NZ_CP028487:89265-89582 [Yersinia massiliensis]
MSLIPAHEWGLKNDIVPRFGARLVQEGNRLHYLADRAGLTGNFTPEQLQALERSFPALTEQLENLLRTGELNPRQQHLVA
VHFAGFTCIADTCGSCGYVYITIYL

Nucleotide

• Length: 318 bp

>AT101324 NZ_CP028487:89265-89582 [Yersinia massiliensis]
ATGTCATTAATACCAGCCCATGAATGGGGGCTAAAAAACGATATTGTTCCACGTTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTGCATTATTTAGCAGACAGGGCCGGGTTGACGGGAAACTTTACCCCTGAGCAGCTGCAGGCTTTAGAGCGAT
CTTTCCCAGCGCTCACAGAACAACTTGAAAATCTGCTGCGTACCGGCGAGCTAAACCCGCGCCAGCAACACCTGGTAGCA
GTTCACTTTGCCGGGTTTACCTGCATAGCGGATACCTGTGGTAGCTGTGGCTACGTTTACATCACCATTTATCTTTAG