10132

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 694126..694709 Replicon chromosome
Accession CP012111
Organism Acetobacter pasteurianus strain Ab3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DB34_03210 Protein ID AKR48062.1
Coordinates 694455..694709 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DB34_03205 Protein ID AKR48061.1
Coordinates 694126..694458 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DB34_03185 689428..691653 - 2226 AKR48059.1 hypothetical protein -
DB34_03195 693474..693785 + 312 ALR88179.1 hypothetical protein -
DB34_03200 693791..694084 + 294 AKR48060.1 hypothetical protein -
DB34_03205 694126..694458 - 333 AKR48061.1 DNA repair protein Antitoxin
DB34_03210 694455..694709 - 255 AKR48062.1 hexulose-6-phosphate synthase Toxin
DB34_03215 694775..695713 - 939 AKR48063.1 hypothetical protein -
DB34_03220 696001..697212 - 1212 AKR48064.1 integrase -
DB34_03225 697439..699232 - 1794 AKR48065.1 multidrug ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9479.92 Da        Isoelectric Point: 10.3861

>T10132 AKR48062.1 CP012111:c694709-694455 [Acetobacter pasteurianus]
MKAKHRRTLELIFKRPVSGNVPWADIEALFVSLGAEVSEREGSRIGVFLFDEVKVFHRPHPKPDTDKGAVASVRKWLEQN
GVTP

Download         Length: 255 bp

>T10132 CP012111:c694709-694455 [Acetobacter pasteurianus]
ATGAAAGCCAAGCACCGCCGCACATTGGAGTTGATTTTCAAACGTCCTGTTTCGGGCAATGTGCCATGGGCAGACATTGA
AGCTTTGTTTGTTTCTCTTGGGGCGGAGGTGTCTGAAAGAGAAGGCTCCCGCATAGGGGTGTTCCTGTTTGATGAGGTGA
AGGTGTTTCACAGACCTCACCCCAAACCGGATACCGACAAGGGTGCCGTAGCCTCTGTGCGAAAATGGCTTGAGCAGAAT
GGAGTGACGCCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11962.61 Da        Isoelectric Point: 4.6856

>AT10132 AKR48061.1 CP012111:c694458-694126 [Acetobacter pasteurianus]
MNNVMEIGGHRAVIQFDPEIGMFRGEFLGLNGGADFYADSVAGLQQEGEASLRVFMEMCAEKGIDPVKHYSGRFVVRLPE
EVHARAVEIAAARGVSLNRLVQDALAQVEG

Download         Length: 333 bp

>AT10132 CP012111:c694458-694126 [Acetobacter pasteurianus]
ATGAACAACGTAATGGAAATTGGCGGCCATCGGGCTGTTATTCAGTTTGATCCTGAAATCGGGATGTTTCGGGGCGAGTT
TCTGGGACTGAACGGAGGGGCTGATTTCTACGCAGATAGTGTGGCAGGCCTTCAGCAGGAAGGGGAAGCTTCCCTCCGTG
TATTCATGGAGATGTGCGCCGAAAAGGGCATTGATCCCGTGAAGCATTATTCAGGCCGGTTTGTTGTGAGATTGCCGGAA
GAGGTCCATGCACGGGCAGTCGAGATTGCTGCAGCACGTGGTGTCAGTCTTAACCGCCTAGTGCAGGATGCTCTGGCGCA
GGTTGAAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References

(1) Kai Xia et al. (2019) Characterization and comparative analysis of toxin-antitoxin systems in Acetobacter pasteurianus. Journal of Industrial Microbiology & Biotechnology 46(6):869-882. [PubMed:30805740] experimental


experimental experimental literature