Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 819134..819968 Replicon chromosome
Accession NZ_CP028483
Organism Escherichia coli strain E41-1

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag C2U19_RS04215 Protein ID WP_000854690.1
Coordinates 819134..819511 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag C2U19_RS04220 Protein ID WP_001305076.1
Coordinates 819600..819968 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U19_RS27920 815528..815683 - 156 WP_000729638.1 hypothetical protein -
C2U19_RS04190 816115..817048 - 934 Protein_773 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
C2U19_RS04195 817041..817436 - 396 WP_000208384.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
C2U19_RS04200 817505..818350 - 846 WP_001529401.1 DUF4942 domain-containing protein -
C2U19_RS04205 818435..818632 - 198 WP_000839293.1 DUF957 domain-containing protein -
C2U19_RS04210 818649..819137 - 489 WP_000761699.1 hypothetical protein -
C2U19_RS04215 819134..819511 - 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
C2U19_RS04220 819600..819968 - 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U19_RS04225 820018..820662 - 645 WP_000094916.1 hypothetical protein -
C2U19_RS04230 820681..820902 - 222 WP_000692329.1 DUF987 domain-containing protein -
C2U19_RS04235 820965..821441 - 477 WP_001186726.1 RadC family protein -
C2U19_RS04240 821457..821942 - 486 WP_000849565.1 antirestriction protein -
C2U19_RS04245 821997..822814 - 818 Protein_784 DUF932 domain-containing protein -
C2U19_RS04255 822915..823148 - 234 WP_000902034.1 DUF905 family protein -
C2U19_RS04260 823227..823682 - 456 WP_000581502.1 hypothetical protein -
C2U19_RS04265 823758..824885 - 1128 Protein_787 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / sat 799584..868179 68595
- flank IS/Tn - - 815528..815683 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T101287 WP_000854690.1 NZ_CP028483:c819511-819134 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T101287 NZ_CP028483:c819511-819134 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT101287 WP_001305076.1 NZ_CP028483:c819968-819600 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT101287 NZ_CP028483:c819968-819600 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References