Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 2019664..2020229 | Replicon | chromosome |
| Accession | NZ_CP028481 | ||
| Organism | Vibrio parahaemolyticus strain S107-1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W588 |
| Locus tag | DA442_RS10410 | Protein ID | WP_023667331.1 |
| Coordinates | 2019664..2019951 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | DA442_RS10415 | Protein ID | WP_023667330.1 |
| Coordinates | 2019948..2020229 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DA442_RS10350 | 2015228..2015683 | - | 456 | WP_180801385.1 | GNAT family N-acetyltransferase | - |
| DA442_RS10355 | 2015689..2015798 | - | 110 | Protein_1878 | DUF3265 domain-containing protein | - |
| DA442_RS10360 | 2015823..2016236 | - | 414 | WP_031846525.1 | hypothetical protein | - |
| DA442_RS10365 | 2016265..2016357 | - | 93 | WP_079771031.1 | DUF3265 domain-containing protein | - |
| DA442_RS10370 | 2016384..2017342 | - | 959 | Protein_1881 | phosphotransferase | - |
| DA442_RS10375 | 2017520..2017879 | - | 360 | WP_031846647.1 | hypothetical protein | - |
| DA442_RS10380 | 2017908..2017967 | - | 60 | WP_072599420.1 | hypothetical protein | - |
| DA442_RS10390 | 2018395..2018487 | - | 93 | WP_079771027.1 | DUF3265 domain-containing protein | - |
| DA442_RS10395 | 2018502..2018942 | - | 441 | WP_134990609.1 | hypothetical protein | - |
| DA442_RS10400 | 2019088..2019495 | - | 408 | WP_025523877.1 | OsmC family protein | - |
| DA442_RS10405 | 2019545..2019661 | - | 117 | WP_078532102.1 | DUF3265 domain-containing protein | - |
| DA442_RS10410 | 2019664..2019951 | - | 288 | WP_023667331.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DA442_RS10415 | 2019948..2020229 | - | 282 | WP_023667330.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| DA442_RS10420 | 2020320..2020450 | - | 131 | Protein_1890 | DUF3265 domain-containing protein | - |
| DA442_RS10435 | 2021488..2022420 | - | 933 | WP_031846558.1 | DUF4238 domain-containing protein | - |
| DA442_RS10445 | 2022562..2022882 | - | 321 | WP_031846557.1 | DUF2834 domain-containing protein | - |
| DA442_RS26005 | 2023265..2023567 | - | 303 | WP_079771120.1 | hypothetical protein | - |
| DA442_RS10455 | 2023648..2024211 | - | 564 | WP_031846556.1 | hypothetical protein | - |
| DA442_RS10460 | 2024239..2024328 | - | 90 | WP_079749020.1 | DUF3265 domain-containing protein | - |
| DA442_RS10465 | 2024839..2024928 | - | 90 | Protein_1896 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1918267..2031908 | 113641 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10949.53 Da Isoelectric Point: 5.0980
>T101282 WP_023667331.1 NZ_CP028481:c2019951-2019664 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV
Download Length: 288 bp
>T101282 NZ_CP028481:c2019951-2019664 [Vibrio parahaemolyticus]
ATGAAAGTAGTTTGGTCTCCTTTGGCTCTTCAAAAGCTTGGTGATGCTGCTGAATTTATTTCACTAGACAATCCGTCTGC
TGCTGAAAAGTGGGTAAATGACGTTTTCGATAAAACTGAATCACTCGGAAGTATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATACCCCATACAAACTATCGTGAAATCATTTTCGGTCACTATCGTATTATTTATAGTTTAAGCCACGAAATTCGTGTG
TTAACAGTTCGTAATTGTCGTCAGATTTTGACGGAAGATGACGTGTAA
ATGAAAGTAGTTTGGTCTCCTTTGGCTCTTCAAAAGCTTGGTGATGCTGCTGAATTTATTTCACTAGACAATCCGTCTGC
TGCTGAAAAGTGGGTAAATGACGTTTTCGATAAAACTGAATCACTCGGAAGTATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATACCCCATACAAACTATCGTGAAATCATTTTCGGTCACTATCGTATTATTTATAGTTTAAGCCACGAAATTCGTGTG
TTAACAGTTCGTAATTGTCGTCAGATTTTGACGGAAGATGACGTGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10427.94 Da Isoelectric Point: 5.1991
>AT101282 WP_023667330.1 NZ_CP028481:c2020229-2019948 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK
Download Length: 282 bp
>AT101282 NZ_CP028481:c2020229-2019948 [Vibrio parahaemolyticus]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCGCTATCTGAGTTTCGTGCCGGTGTAGCTTCTTACATCAAACAAAT
CAATGAGACTCGTCGTCCGTTGGTAATTACACAACGCGGTAAAGGTGTTGCTGTTGTTCTTGATGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAGTTACTGGAAGAAATGCGCACAGCAGAAGCTCAATTAGCTTCAGGTCTTGGTGTTTCAAAT
GAAGAAGCGCGCGCTGAGGTTTTAGGGCGCATTAAGAAATGA
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCGCTATCTGAGTTTCGTGCCGGTGTAGCTTCTTACATCAAACAAAT
CAATGAGACTCGTCGTCCGTTGGTAATTACACAACGCGGTAAAGGTGTTGCTGTTGTTCTTGATGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAGTTACTGGAAGAAATGCGCACAGCAGAAGCTCAATTAGCTTCAGGTCTTGGTGTTTCAAAT
GAAGAAGCGCGCGCTGAGGTTTTAGGGCGCATTAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|