Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2008578..2009094 Replicon chromosome
Accession NZ_CP028481
Organism Vibrio parahaemolyticus strain S107-1

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag DA442_RS10260 Protein ID WP_005464459.1
Coordinates 2008578..2008847 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag DA442_RS10265 Protein ID WP_005483180.1
Coordinates 2008840..2009094 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA442_RS10195 2003824..2003913 - 90 WP_078532205.1 DUF3265 domain-containing protein -
DA442_RS10200 2003945..2004793 - 849 WP_031846385.1 DUF2971 domain-containing protein -
DA442_RS10210 2005249..2005788 - 540 WP_031846387.1 hypothetical protein -
DA442_RS10215 2005842..2005934 - 93 WP_078532203.1 DUF3265 domain-containing protein -
DA442_RS10220 2005961..2006254 - 294 WP_031846508.1 hypothetical protein -
DA442_RS10225 2006566..2006799 - 234 WP_134990606.1 hypothetical protein -
DA442_RS10235 2006954..2007352 - 399 WP_031846510.1 hypothetical protein -
DA442_RS10240 2007421..2007558 - 138 WP_078532204.1 DUF3265 domain-containing protein -
DA442_RS10250 2007968..2008060 - 93 WP_192947862.1 DUF3265 domain-containing protein -
DA442_RS10255 2008075..2008416 - 342 WP_031846593.1 hypothetical protein -
DA442_RS10260 2008578..2008847 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
DA442_RS10265 2008840..2009094 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DA442_RS10270 2009186..2009308 - 123 WP_072599535.1 DUF3265 domain-containing protein -
DA442_RS10275 2009305..2009838 - 534 WP_176134381.1 (d)CMP kinase -
DA442_RS10280 2009878..2009967 - 90 WP_078532231.1 DUF3265 domain-containing protein -
DA442_RS26000 2010421..2010588 - 168 WP_001883086.1 DUF3265 domain-containing protein -
DA442_RS10290 2010528..2010830 - 303 WP_134990607.1 hypothetical protein -
DA442_RS10295 2010861..2010953 - 93 WP_079766442.1 DUF3265 domain-containing protein -
DA442_RS10300 2010968..2011321 - 354 WP_031829440.1 hypothetical protein -
DA442_RS10305 2011531..2012106 - 576 WP_064484110.1 hypothetical protein -
DA442_RS10310 2012250..2012747 - 498 WP_031846617.1 DinB family protein -
DA442_RS10320 2012961..2013170 - 210 WP_031846616.1 DUF3955 domain-containing protein -
DA442_RS10325 2013271..2013360 - 90 WP_074531745.1 DUF3265 domain-containing protein -
DA442_RS10330 2013392..2013760 - 369 WP_017449638.1 VOC family protein -
DA442_RS10335 2013790..2013927 - 138 WP_079771029.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1918267..2031908 113641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T101281 WP_005464459.1 NZ_CP028481:c2008847-2008578 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T101281 NZ_CP028481:c2008847-2008578 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTATTATCGTGGACTGATGATGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATTGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCATGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT101281 WP_005483180.1 NZ_CP028481:c2009094-2008840 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT101281 NZ_CP028481:c2009094-2008840 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAGGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACTGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References