Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1997221..1997768 Replicon chromosome
Accession NZ_CP028481
Organism Vibrio parahaemolyticus strain S107-1

Toxin (Protein)


Gene name relE Uniprot ID A0A7Z2MSV0
Locus tag DA442_RS10130 Protein ID WP_025527253.1
Coordinates 1997221..1997523 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag DA442_RS10135 Protein ID WP_005448240.1
Coordinates 1997511..1997768 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA442_RS10070 1992262..1992654 - 393 WP_031846623.1 hypothetical protein -
DA442_RS10075 1992812..1993216 - 405 WP_031846622.1 DUF1801 domain-containing protein -
DA442_RS10085 1993354..1994367 - 1014 WP_031846621.1 hypothetical protein -
DA442_RS10090 1994512..1994880 - 369 WP_031846627.1 hypothetical protein -
DA442_RS10095 1994893..1995054 - 162 Protein_1832 DUF3265 domain-containing protein -
DA442_RS10105 1995381..1995473 - 93 WP_079771035.1 DUF3265 domain-containing protein -
DA442_RS10110 1995488..1996594 - 1107 WP_134990605.1 hypothetical protein -
DA442_RS10115 1996626..1996718 - 93 WP_074050578.1 DUF3265 domain-containing protein -
DA442_RS10120 1996733..1997065 - 333 WP_064484111.1 hypothetical protein -
DA442_RS10125 1997093..1997185 - 93 WP_079771034.1 DUF3265 domain-containing protein -
DA442_RS10130 1997221..1997523 - 303 WP_025527253.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DA442_RS10135 1997511..1997768 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DA442_RS10140 1997939..1998373 - 435 WP_025441728.1 GNAT family N-acetyltransferase -
DA442_RS10145 1998489..1999121 - 633 WP_031846520.1 DUF2971 domain-containing protein -
DA442_RS10150 1999270..1999716 - 447 WP_031846521.1 GNAT family N-acetyltransferase -
DA442_RS10155 1999745..1999837 - 93 WP_074190183.1 DUF3265 domain-containing protein -
DA442_RS10160 1999852..2000346 - 495 WP_025630543.1 hypothetical protein -
DA442_RS10165 2000382..2000513 - 132 WP_079771033.1 DUF3265 domain-containing protein -
DA442_RS10175 2001002..2001091 - 90 WP_079771037.1 DUF3265 domain-containing protein -
DA442_RS10180 2001612..2001752 - 141 WP_079771036.1 DUF3265 domain-containing protein -
DA442_RS10185 2001724..2002140 - 417 WP_031846305.1 VOC family protein -
DA442_RS26110 2002315..2002566 - 252 WP_209019883.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1918267..2031908 113641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11640.53 Da        Isoelectric Point: 4.8951

>T101280 WP_025527253.1 NZ_CP028481:c1997523-1997221 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T101280 NZ_CP028481:c1997523-1997221 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAGTCGGGTCGTATTCCGC
CTGAACTAGAACATCTAAGCTATCGTGAAGTTGTAGTTAATCCGTGCCGCGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTAATGCGTGCTGAGAGAGACTTACGTAAGTTCCTATTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT101280 WP_005448240.1 NZ_CP028481:c1997768-1997511 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT101280 NZ_CP028481:c1997768-1997511 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAAATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCGGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7Z2MSV0


Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References