Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796887..797544 Replicon chromosome
Accession NZ_CP028478
Organism Klebsiella pneumoniae strain 2e

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DA795_RS04035 Protein ID WP_002916310.1
Coordinates 797134..797544 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DA795_RS04030 Protein ID WP_002916312.1
Coordinates 796887..797153 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA795_RS04005 792043..793476 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
DA795_RS04010 793595..794323 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DA795_RS04015 794373..794684 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DA795_RS04020 794848..795507 + 660 WP_002916317.1 hemolysin III family protein -
DA795_RS04025 795658..796641 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
DA795_RS04030 796887..797153 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DA795_RS04035 797134..797544 + 411 WP_002916310.1 protein YgfX Toxin
DA795_RS04040 797551..798072 - 522 WP_004144730.1 flavodoxin FldB -
DA795_RS04045 798173..799069 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DA795_RS04050 799092..799805 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DA795_RS04055 799811..801544 + 1734 WP_108452515.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T101260 WP_002916310.1 NZ_CP028478:797134-797544 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T101260 NZ_CP028478:797134-797544 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT101260 WP_002916312.1 NZ_CP028478:796887-797153 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT101260 NZ_CP028478:796887-797153 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References