Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2075739..2076268 Replicon chromosome
Accession NZ_CP028468
Organism Staphylococcus aureus strain IT1-S

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C5Y45_RS10610 Protein ID WP_000621175.1
Coordinates 2075739..2076101 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C5Y45_RS10615 Protein ID WP_000948330.1
Coordinates 2076098..2076268 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5Y45_RS10585 2072718..2073488 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
C5Y45_RS10590 2073463..2073942 - 480 WP_001190825.1 anti-sigma B factor RsbW -
C5Y45_RS10595 2073944..2074270 - 327 WP_001052491.1 anti-sigma factor antagonist -
C5Y45_RS10600 2074390..2075391 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
C5Y45_RS10610 2075739..2076101 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C5Y45_RS10615 2076098..2076268 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
C5Y45_RS10620 2076353..2077501 - 1149 WP_001281141.1 alanine racemase -
C5Y45_RS10625 2077567..2077926 - 360 WP_000581193.1 holo-ACP synthase -
C5Y45_RS10630 2077930..2078421 - 492 WP_001205918.1 PH domain-containing protein -
C5Y45_RS10635 2078408..2079991 - 1584 WP_001294624.1 PH domain-containing protein -
C5Y45_RS10640 2079984..2080463 - 480 WP_001287080.1 hypothetical protein -
C5Y45_RS10645 2080672..2081232 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T101233 WP_000621175.1 NZ_CP028468:c2076101-2075739 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T101233 NZ_CP028468:c2076101-2075739 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT101233 WP_000948330.1 NZ_CP028468:c2076268-2076098 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT101233 NZ_CP028468:c2076268-2076098 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References