Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 813669..814146 Replicon chromosome
Accession NZ_CP028468
Organism Staphylococcus aureus strain IT1-S

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag C5Y45_RS03945 Protein ID WP_000052076.1
Coordinates 813669..813857 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C5Y45_RS03950 Protein ID WP_001059690.1
Coordinates 813886..814146 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5Y45_RS03915 809659..810180 + 522 WP_000824488.1 hypothetical protein -
C5Y45_RS03920 810521..811207 + 687 WP_001670297.1 thermonuclease family protein -
C5Y45_RS03925 811564..811764 + 201 WP_001059082.1 cold-shock protein -
C5Y45_RS03930 812260..812478 - 219 WP_000005876.1 hypothetical protein -
C5Y45_RS03935 812540..812824 - 285 WP_001004395.1 hypothetical protein -
C5Y45_RS03940 812912..813481 - 570 WP_001106646.1 hypothetical protein -
C5Y45_RS03945 813669..813857 - 189 WP_000052076.1 hypothetical protein Toxin
C5Y45_RS03950 813886..814146 - 261 WP_001059690.1 hypothetical protein Antitoxin
C5Y45_RS03955 814486..814689 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C5Y45_RS03960 814686..814922 - 237 WP_000368687.1 hypothetical protein -
C5Y45_RS03965 815147..815728 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
C5Y45_RS03970 815801..816418 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
C5Y45_RS03975 816572..817066 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
C5Y45_RS03980 817465..817887 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
C5Y45_RS03985 818035..818751 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-106)

Antitoxin

Helix-turn-helix domain, group 17

(54-102)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T101226 WP_000052076.1 NZ_CP028468:c813857-813669 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T101226 NZ_CP028468:c813857-813669 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT101226 WP_001059690.1 NZ_CP028468:c814146-813886 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT101226 NZ_CP028468:c814146-813886 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References