Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | EcnAB/- |
| Location | 4700598..4700959 | Replicon | chromosome |
| Accession | NC_003919 | ||
| Organism | Xanthomonas axonopodis pv. citri str. 306 | ||
Toxin (Protein)
| Gene name | EcnB | Uniprot ID | M4UGA1 |
| Locus tag | XAC_RS20185 | Protein ID | WP_005914328.1 |
| Coordinates | 4700598..4700732 (-) | Length | 45 a.a. |
Antitoxin (Protein)
| Gene name | EcnA | Uniprot ID | H8FG64 |
| Locus tag | XAC_RS20190 | Protein ID | WP_003486606.1 |
| Coordinates | 4700807..4700959 (-) | Length | 51 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XAC_RS20165 (XAC4004) | 4695736..4697427 | - | 1692 | WP_015471463.1 | M20/M25/M40 family metallo-hydrolase | - |
| XAC_RS20170 (XAC4005) | 4697619..4698653 | - | 1035 | WP_011052671.1 | MBL fold metallo-hydrolase | - |
| XAC_RS20175 (XAC4006) | 4698692..4699981 | - | 1290 | WP_015463705.1 | tryptophan--tRNA ligase | - |
| XAC_RS20180 (XAC4007) | 4700162..4700371 | - | 210 | WP_003486601.1 | CsbD family protein | - |
| XAC_RS20185 | 4700598..4700732 | - | 135 | WP_005914328.1 | entericidin A/B family lipoprotein | Toxin |
| XAC_RS20190 (XAC4008) | 4700807..4700959 | - | 153 | WP_003486606.1 | entericidin A/B family lipoprotein | Antitoxin |
| XAC_RS20195 (XAC4009) | 4701066..4701989 | - | 924 | WP_005927745.1 | arginase | - |
| XAC_RS20200 (XAC4010) | 4702310..4702762 | + | 453 | WP_003486611.1 | roadblock/LC7 domain-containing protein | - |
| XAC_RS20205 (XAC4011) | 4702826..4703185 | + | 360 | WP_003486613.1 | hypothetical protein | - |
| XAC_RS20210 (XAC4012) | 4703282..4704199 | + | 918 | WP_011052673.1 | hypothetical protein | - |
| XAC_RS20215 (XAC4013) | 4704196..4704738 | + | 543 | WP_003486615.1 | GTPase | - |
| XAC_RS20220 (XAC4014) | 4705176..4705859 | + | 684 | WP_011052674.1 | dTMP kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 45 a.a. Molecular weight: 4459.32 Da Isoelectric Point: 9.3487
>T10118 WP_005914328.1 NC_003919:c4700732-4700598 [Xanthomonas citri pv. citri str. 306]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK
Download Length: 135 bp
>T10118 NC_003919:c4700732-4700598 [Xanthomonas citri pv. citri str. 306]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
Antitoxin
Download Length: 51 a.a. Molecular weight: 5122.07 Da Isoelectric Point: 8.7942
>AT10118 WP_003486606.1 NC_003919:c4700959-4700807 [Xanthomonas citri pv. citri str. 306]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC
Download Length: 153 bp
>AT10118 NC_003919:c4700959-4700807 [Xanthomonas citri pv. citri str. 306]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G2W7U6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828YLX6 |
References
(1) Laís Moreira Granato et al. (2019) The ecnA Antitoxin Is Important Not Only for Human Pathogens: Evidence of Its Role in the Plant Pathogen Xanthomonas citri subsp. citri. Journal of Bacteriology 201(20):e00796-18. [PubMed:31358614]