Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 962827..964073 Replicon chromosome
Accession NZ_CP028415
Organism Streptococcus mitis strain SK637

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag SK637_RS05060 Protein ID WP_033688819.1
Coordinates 962827..963597 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag SK637_RS05065 Protein ID WP_033688820.1
Coordinates 963597..964073 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK637_RS05035 958407..958973 - 567 WP_033688814.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
SK637_RS05040 959067..959291 - 225 WP_033688815.1 hypothetical protein -
SK637_RS05045 959296..959997 - 702 WP_033688816.1 hypothetical protein -
SK637_RS05050 960321..961319 - 999 WP_033688817.1 hypothetical protein -
SK637_RS05055 961568..962374 - 807 WP_033688818.1 hypothetical protein -
SK637_RS05060 962827..963597 - 771 WP_033688819.1 zeta toxin family protein Toxin
SK637_RS05065 963597..964073 - 477 WP_033688820.1 helix-turn-helix domain-containing protein Antitoxin
SK637_RS05070 964418..964915 - 498 WP_050489876.1 hypothetical protein -
SK637_RS05075 965190..966929 - 1740 WP_033688821.1 glycoside hydrolase family 13 protein -
SK637_RS05080 967091..967594 - 504 WP_033688822.1 phosphoribosylanthranilate isomerase -
SK637_RS05085 967658..968539 - 882 WP_033688823.1 diacylglycerol kinase family lipid kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island msr(D) / mef(A) - 949252..975365 26113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(24-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29417.31 Da        Isoelectric Point: 7.1724

>T101147 WP_033688819.1 NZ_CP028415:c963597-962827 [Streptococcus mitis]
VEIQDYTDSEFKHALARNIRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFSGKMVESLVTELSYFGYNLLIEGTLRTIDVPKKTAQLLKNMGYEVQLALIATKSKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCIYDSKENTTSAATVLHDLLFGEWNQVEKEML
RSGEERLKDLTNRNGC

Download         Length: 771 bp

>T101147 NZ_CP028415:c963597-962827 [Streptococcus mitis]
GTGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAGCGCGGAACATTCGCTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCTGGCAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTATTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTTGAATACACCAAAGATTTTTCAGGTAAAATGGTAGAATCTTTAGTAACAGAATTGAGTTA
TTTTGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
TGGGATATGAAGTGCAATTAGCCTTGATTGCGACAAAGTCTAAGCTGTCCTATCTGAGCACTCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGGCAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTATATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AGATCTGGAGAGGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18173.62 Da        Isoelectric Point: 4.4735

>AT101147 WP_033688820.1 NZ_CP028415:c964073-963597 [Streptococcus mitis]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLGISEKRMVA

Download         Length: 477 bp

>AT101147 NZ_CP028415:c964073-963597 [Streptococcus mitis]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCTGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGTTTGAGTCGTTATGAAAATGGCACTAGTTCAGTCTCTACGGAACTAATAGATATCATCTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTGAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATCGTGAAAGAAAGAGGTGCTAATCTACTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTTTCTGATTTGATTCATACGAATATCTATCTAGTTGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGGGATATCTGAAAAACGGATGGTGGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References