Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 495692..496319 Replicon chromosome
Accession NZ_CP028415
Organism Streptococcus mitis strain SK637

Toxin (Protein)


Gene name parE Uniprot ID A0A081QIB3
Locus tag SK637_RS02770 Protein ID WP_000384865.1
Coordinates 495969..496319 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S7ZA41
Locus tag SK637_RS02765 Protein ID WP_020901685.1
Coordinates 495692..495979 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK637_RS02740 491475..492314 + 840 WP_001192010.1 carbohydrate ABC transporter permease -
SK637_RS02745 492487..492939 + 453 WP_033688295.1 YhcH/YjgK/YiaL family protein -
SK637_RS02750 492959..493603 + 645 WP_000057475.1 DUF624 domain-containing protein -
SK637_RS02755 493776..494693 + 918 WP_033688296.1 dihydrodipicolinate synthase family protein -
SK637_RS02760 494711..495595 + 885 WP_033688298.1 ROK family protein -
SK637_RS02765 495692..495979 + 288 WP_020901685.1 XRE family transcriptional regulator Antitoxin
SK637_RS02770 495969..496319 + 351 WP_000384865.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SK637_RS02775 496381..497232 - 852 WP_033688299.1 MurR/RpiR family transcriptional regulator -
SK637_RS02780 497425..499482 + 2058 WP_080710461.1 penicillin-binding protein PBP2B -
SK637_RS02785 499493..500089 + 597 WP_000966754.1 recombination mediator RecR -
SK637_RS02790 500265..501308 + 1044 WP_033688303.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13704.84 Da        Isoelectric Point: 9.8158

>T101146 WP_000384865.1 NZ_CP028415:495969-496319 [Streptococcus mitis]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVESARRKVASIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGLALSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T101146 NZ_CP028415:495969-496319 [Streptococcus mitis]
ATGGATTATAAAAAATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTTTGGATAAAATATATCAGTATATAGCAGA
GGAAATCGGTTCTGTAGAGTCTGCGAGACGAAAAGTGGCGAGTATCAGAAAAGATATTAATCGTCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGACCCTCGCTACCAAACGCGAGGATTGGCCTTGAGTAAG
GATTATATTGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTTCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACTAAGTCGAGATATGACTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10788.19 Da        Isoelectric Point: 4.2298

>AT101146 WP_020901685.1 NZ_CP028415:495692-495979 [Streptococcus mitis]
MAIANSSKVVTFQANRELVNDAMEVLKEKNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT101146 NZ_CP028415:495692-495979 [Streptococcus mitis]
ATGGCTATAGCAAATTCAAGTAAAGTTGTGACCTTCCAAGCTAATAGAGAATTAGTAAATGATGCCATGGAAGTGTTAAA
AGAAAAAAATCTCTCTCTTTCATCGGCACTTAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTTA
GTGAAGAGGAATTGGAGAAGGAGTATTTATTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCTAAGATTGAGGCT
GGGAATTACTTGACAGATGAGGATGTTGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081QIB3

Antitoxin

Source ID Structure
AlphaFold DB S7ZA41

References