Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 487759..488386 Replicon chromosome
Accession NZ_CP028414
Organism Streptococcus mitis NCTC 12261

Toxin (Protein)


Gene name parE Uniprot ID I0SM96
Locus tag SM12261_RS02730 Protein ID WP_000384864.1
Coordinates 488036..488386 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1X1KIL2
Locus tag SM12261_RS02725 Protein ID WP_000951984.1
Coordinates 487759..488046 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM12261_RS02700 483542..484381 + 840 WP_001192117.1 carbohydrate ABC transporter permease -
SM12261_RS02705 484554..485006 + 453 WP_000575452.1 YhcH/YjgK/YiaL family protein -
SM12261_RS02710 485026..485670 + 645 WP_000057476.1 DUF624 domain-containing protein -
SM12261_RS02715 485843..486760 + 918 WP_001281493.1 dihydrodipicolinate synthase family protein -
SM12261_RS02720 486778..487662 + 885 WP_000150262.1 ROK family protein -
SM12261_RS02725 487759..488046 + 288 WP_000951984.1 hypothetical protein Antitoxin
SM12261_RS02730 488036..488386 + 351 WP_000384864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SM12261_RS02735 488448..489299 - 852 WP_000360341.1 MurR/RpiR family transcriptional regulator -
SM12261_RS02740 489491..491548 + 2058 WP_004238750.1 penicillin-binding protein PBP2B -
SM12261_RS02745 491559..492155 + 597 WP_000966754.1 recombination mediator RecR -
SM12261_RS02750 492330..493373 + 1044 WP_000814640.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13718.86 Da        Isoelectric Point: 9.8158

>T101142 WP_000384864.1 NZ_CP028414:488036-488386 [Streptococcus mitis NCTC 12261]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVASIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T101142 NZ_CP028414:488036-488386 [Streptococcus mitis NCTC 12261]
ATGGATTATAAAAAATATCGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGACAAAATATATCAGTATATAGCGGA
GGAAATTGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCCAGTATTAGAAAAGATATTAATCGTCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGACCCTCGCTACCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACCAAGTCAAGATATGACTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10829.20 Da        Isoelectric Point: 4.1285

>AT101142 WP_000951984.1 NZ_CP028414:487759-488046 [Streptococcus mitis NCTC 12261]
MAIANSNKIVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT101142 NZ_CP028414:487759-488046 [Streptococcus mitis NCTC 12261]
ATGGCTATAGCGAATTCAAATAAAATTGTGACCTTCCAAGCTAATAGAGAATTGGTAAATGATGCCATGGAAGTGTTAAA
AGAACAAAATCTCTCTCTTTCATCAGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAAGGAGTATTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAGATTGAGGCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0SM96

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1KIL2

References