Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 847890..848547 Replicon chromosome
Accession NZ_CP028391
Organism Klebsiella pneumoniae strain WCHKP13F2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag B7D34_RS06740 Protein ID WP_002916310.1
Coordinates 848137..848547 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B7D34_RS06735 Protein ID WP_002916312.1
Coordinates 847890..848156 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D34_RS06710 843046..844479 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
B7D34_RS06715 844598..845326 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
B7D34_RS06720 845376..845687 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
B7D34_RS06725 845851..846510 + 660 WP_002916317.1 hemolysin III family protein -
B7D34_RS06730 846661..847644 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
B7D34_RS06735 847890..848156 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B7D34_RS06740 848137..848547 + 411 WP_002916310.1 protein YgfX Toxin
B7D34_RS06745 848554..849075 - 522 WP_002916308.1 flavodoxin FldB -
B7D34_RS06750 849176..850072 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
B7D34_RS06755 850095..850808 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B7D34_RS06760 850814..852547 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T101126 WP_002916310.1 NZ_CP028391:848137-848547 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T101126 NZ_CP028391:848137-848547 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT101126 WP_002916312.1 NZ_CP028391:847890-848156 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT101126 NZ_CP028391:847890-848156 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References