Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4256419..4258004 Replicon chromosome
Accession NZ_CP028384
Organism Providencia heimbachae strain 99101

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C9446_RS19820 Protein ID WP_137022376.1
Coordinates 4256419..4257747 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C9446_RS19825 Protein ID WP_137022377.1
Coordinates 4257747..4258004 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9446_RS19810 4252355..4255402 - 3048 WP_082913019.1 formate dehydrogenase-N subunit alpha -
C9446_RS19815 4255577..4256407 + 831 WP_137022375.1 formate dehydrogenase accessory sulfurtransferase FdhD -
C9446_RS19820 4256419..4257747 - 1329 WP_137022376.1 type II toxin-antitoxin system HipA family toxin Toxin
C9446_RS19825 4257747..4258004 - 258 WP_137022377.1 helix-turn-helix domain-containing protein Antitoxin
C9446_RS19830 4258162..4259526 - 1365 WP_137022378.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
C9446_RS19835 4259674..4261323 - 1650 WP_068437931.1 membrane protein insertase YidC -
C9446_RS19840 4261326..4261586 - 261 WP_068437928.1 membrane protein insertion efficiency factor YidD -
C9446_RS19845 4261550..4261909 - 360 WP_073889908.1 ribonuclease P protein component -
C9446_RS19850 4261931..4262074 - 144 WP_068437925.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50478.73 Da        Isoelectric Point: 5.6982

>T101117 WP_137022376.1 NZ_CP028384:c4257747-4256419 [Providencia heimbachae]
MATLHVYMNGYLVGEFIRLSTGAHQFKYDIHWLETPGARPISLSMPLQYQEYKGDEVYNFFDNLLPDNSEIRKRVVRRYR
AESTQPFDLLSKIGQDSVGALQLVPNELNVSDIKKIEYRPLSDEALEKVLNGYKSDIPLGMIEEVDDFRISIAGAQEKTA
LLYFNDQWCLPLRTTPTTHIIKLPIGEIQSHSHTLDMSDSVENEFLCLLIAAEFGFDVPKCTIINVGETKALAVERFDRK
FSADNAWIMRLPQEDFCQTLNVLSENKYQKDGGPGIYDIMTYLLGSINTEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYKLTPFYDILSVYPVFGGKGLNPREAKLAMSLKGTKGTKGNKDKIEQIFPRHFFATAKAVGFDRTEMERIFIEFD
EQMESVITKVRDQLPADFPEHIANSILSGLQSKATRLKKGWD

Download         Length: 1329 bp

>T101117 NZ_CP028384:c4257747-4256419 [Providencia heimbachae]
ATGGCGACTTTGCATGTGTATATGAATGGTTATCTTGTGGGTGAATTTATTCGCTTAAGTACTGGAGCGCATCAATTTAA
ATATGATATTCACTGGTTGGAAACGCCGGGTGCTCGTCCTATCTCTTTATCAATGCCACTTCAGTATCAAGAATACAAAG
GGGACGAAGTTTATAATTTTTTTGATAACTTATTGCCTGATAATTCAGAGATCCGAAAGCGGGTTGTTAGGCGATATAGA
GCGGAATCGACACAGCCTTTTGATTTACTATCCAAGATAGGACAAGACAGTGTTGGTGCATTACAACTTGTTCCTAACGA
ACTTAATGTTAGCGATATTAAAAAAATAGAATATCGACCATTATCCGATGAAGCGTTGGAAAAAGTATTAAACGGATATA
AATCAGATATTCCACTCGGAATGATTGAAGAGGTTGATGATTTTAGGATTTCTATTGCAGGGGCTCAAGAAAAAACTGCC
TTACTTTATTTCAATGACCAGTGGTGCTTGCCACTTAGAACTACGCCTACAACCCACATTATCAAATTGCCTATAGGTGA
AATACAAAGTCATTCTCATACTCTTGATATGTCAGACAGTGTAGAAAATGAATTTCTATGTTTATTGATAGCCGCAGAGT
TTGGTTTTGATGTGCCTAAATGCACTATTATCAATGTGGGAGAAACGAAGGCTCTTGCGGTTGAACGGTTTGACCGTAAA
TTTTCGGCCGATAACGCATGGATTATGCGTTTACCCCAAGAAGACTTCTGCCAAACGTTAAATGTGCTCTCTGAAAATAA
ATATCAAAAGGATGGCGGTCCAGGGATTTACGACATAATGACTTATCTTTTAGGGTCAATAAATACAGAGAAAGATAGAT
ATCAATTTATGAAGAGCCAAGTTCTATTTTGGTTACTTGCTGCCACTGATGGACATGCTAAAAACTTCTCATTATTTATT
GAACCTGAAGGGCGTTATAAATTAACACCTTTTTACGATATTTTGTCAGTATATCCCGTATTTGGCGGTAAAGGACTTAA
TCCAAGAGAGGCAAAATTAGCCATGAGCTTAAAAGGCACGAAAGGCACGAAAGGCAATAAGGATAAAATAGAACAGATTT
TTCCAAGACATTTTTTCGCGACAGCTAAAGCGGTTGGATTTGACCGTACTGAAATGGAAAGAATATTCATTGAGTTTGAT
GAGCAAATGGAAAGTGTCATTACGAAAGTCAGGGATCAACTTCCTGCTGATTTTCCTGAACATATTGCAAACTCAATTTT
GTCGGGATTACAGAGCAAAGCAACACGATTAAAGAAAGGGTGGGATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9696.93 Da        Isoelectric Point: 9.6898

>AT101117 WP_137022377.1 NZ_CP028384:c4258004-4257747 [Providencia heimbachae]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSNFELSPDSTKLETFFKILSALNLELDIKPRNENGSSNTDSG
WKEEW

Download         Length: 258 bp

>AT101117 NZ_CP028384:c4258004-4257747 [Providencia heimbachae]
ATGAAAGTCACCAATACTCGGCAACTTAGTGCTTACATGAAAGATGTCAGAGAAACAAAAAAACTATCCCAAAGCAAAGT
TGCGAGTAAAGTGGGTATTCGGCAAGATACTGTCTCCAATTTTGAACTTTCTCCAGACTCTACCAAATTAGAAACCTTCT
TTAAGATTTTATCTGCATTAAATTTAGAACTCGATATTAAACCCAGAAATGAAAATGGTTCATCAAACACAGACTCCGGA
TGGAAGGAAGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References