Detailed information of TA system TA101115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 3900756..3901341
• Replicon: chromosome
• Accession: NZ_CP028384
• Organism: Providencia heimbachae strain 99101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A4D7IXT5
• Locus tag: C9446_RS18090
• Protein ID: WP_068908523.1
• Coordinates: 3900756..3901070 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C9446_RS18095
• Protein ID: WP_137022281.1
• Coordinates: 3901051..3901341 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9446_RS18060	3896392..3896643	-	252	WP_137022276.1	DUF1471 domain-containing protein	-
C9446_RS18065	3896943..3897242	+	300	WP_137022277.1	GIY-YIG nuclease family protein	-
C9446_RS18070	3897224..3897727	-	504	WP_137022278.1	N-acetyltransferase	-
C9446_RS18075	3897721..3898245	-	525	WP_137022279.1	SCP2 domain-containing protein	-
C9446_RS18080	3898725..3899720	+	996	WP_137022280.1	U32 family peptidase	-
C9446_RS18085	3899735..3900610	+	876	WP_068908521.1	U32 family peptidase	-
C9446_RS18090	3900756..3901070	-	315	WP_068908523.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C9446_RS18095	3901051..3901341	-	291	WP_137022281.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C9446_RS18100	3901444..3902601	-	1158	WP_137022282.1	ABC transporter permease	-
C9446_RS18105	3902601..3903746	-	1146	WP_068439934.1	ABC transporter permease	-
C9446_RS18110	3903757..3904728	-	972	WP_068439932.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (13-104)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-86)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12112.78 Da
• Isoelectric Point: 9.4191

>T101115 WP_068908523.1 NZ_CP028384:c3901070-3900756 [Providencia heimbachae]
MQKLNSKRAKQPRQIAYTSTFKKSWERYNKAGRRDMNEAVIIMEILFSQKTIPAQYFDHELEGSEWKGARELHIGGDFLL
VYRLSDNTNLVTFIDIGSHSELFG

Nucleotide

• Length: 315 bp

>T101115 NZ_CP028384:c3901070-3900756 [Providencia heimbachae]
ATGCAAAAACTAAACAGTAAGCGAGCTAAACAGCCAAGGCAGATTGCTTATACATCGACATTTAAAAAGTCGTGGGAAAG
ATATAATAAAGCAGGTCGTAGGGATATGAATGAGGCAGTAATCATCATGGAGATTTTATTTTCCCAAAAAACGATTCCTG
CACAATATTTTGATCATGAGTTAGAAGGCAGTGAGTGGAAGGGAGCAAGAGAACTTCATATTGGTGGTGATTTTCTTCTG
GTTTATCGGCTCTCGGATAATACGAATTTAGTCACATTTATTGATATTGGATCGCATAGCGAGCTATTTGGTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10869.52 Da
• Isoelectric Point: 5.1970

>AT101115 WP_137022281.1 NZ_CP028384:c3901341-3901051 [Providencia heimbachae]
MTALLKTTDVRSRIDEQLKAEAASVLQDCGLTISAAIRLFLEQVVQEQRIPFEIKRKQPSTKTARALEEATLIEQQYSSL
DEMMLELTKSDAKTKQ

Nucleotide

• Length: 291 bp

>AT101115 NZ_CP028384:c3901341-3901051 [Providencia heimbachae]
ATGACGGCTCTATTAAAAACTACCGATGTTCGTAGTCGTATTGATGAGCAATTAAAAGCTGAGGCTGCAAGTGTTTTGCA
GGACTGTGGGTTAACCATTAGTGCTGCTATTCGTTTGTTCTTAGAACAGGTTGTACAGGAGCAACGTATTCCTTTTGAGA
TTAAACGTAAGCAACCATCTACAAAAACAGCTCGTGCATTAGAGGAAGCGACACTCATTGAACAACAGTATTCTTCCCTT
GATGAGATGATGTTGGAGCTAACAAAAAGTGATGCAAAAACTAAACAGTAA

Structures

Toxin

• AlphaFold DB: A0A4D7IXT5