Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2826862..2827409 Replicon chromosome
Accession NZ_CP028384
Organism Providencia heimbachae strain 99101

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1B7K060
Locus tag C9446_RS13045 Protein ID WP_068907667.1
Coordinates 2827101..2827409 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1B7K057
Locus tag C9446_RS13040 Protein ID WP_068442587.1
Coordinates 2826862..2827101 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9446_RS13020 2822335..2822637 + 303 WP_068907666.1 flagellar biosynthesis anti-sigma factor FlgM -
C9446_RS13025 2822645..2823085 + 441 WP_068442595.1 flagellar export chaperone FlgN -
C9446_RS13030 2823358..2825454 - 2097 WP_068442592.1 flagellar biosynthesis protein FlhA -
C9446_RS13035 2825447..2826598 - 1152 WP_068442590.1 flagellar type III secretion system protein FlhB -
C9446_RS13040 2826862..2827101 + 240 WP_068442587.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C9446_RS13045 2827101..2827409 + 309 WP_068907667.1 CcdB family protein Toxin
C9446_RS13050 2827450..2828007 + 558 WP_137021921.1 hypothetical protein -
C9446_RS13055 2828062..2828361 - 300 WP_137021922.1 helix-turn-helix domain-containing protein -
C9446_RS13060 2828351..2828689 - 339 WP_068446441.1 type II toxin-antitoxin system RelE/ParE family toxin -
C9446_RS13065 2828966..2829604 - 639 WP_068442576.1 protein phosphatase CheZ -
C9446_RS13070 2829629..2830021 - 393 WP_068442573.1 chemotaxis response regulator CheY -
C9446_RS13075 2830062..2831129 - 1068 WP_137021923.1 chemotaxis response regulator protein-glutamate methylesterase -
C9446_RS13080 2831129..2831965 - 837 WP_137022430.1 chemotaxis protein-glutamate O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12000.23 Da        Isoelectric Point: 9.2919

>T101114 WP_068907667.1 NZ_CP028384:2827101-2827409 [Providencia heimbachae]
MQYHLYLNRGDRIRYPYLLDIQSDIIDMLNTRLVIPLYDSKLVQKPLPERLNPIIYIDTHAFILMTHQMASVPLSVLGKK
VIHIKNEREKIKQAIDLLIDGF

Download         Length: 309 bp

>T101114 NZ_CP028384:2827101-2827409 [Providencia heimbachae]
ATGCAATATCACCTTTATCTAAATCGTGGCGATCGTATCCGGTACCCATATTTACTTGATATTCAAAGCGATATTATTGA
TATGCTCAATACTCGTCTCGTTATTCCTTTATATGATAGTAAACTTGTCCAGAAACCATTACCTGAACGATTAAATCCAA
TTATATACATCGATACCCATGCCTTTATTTTAATGACCCATCAAATGGCTTCAGTACCTCTATCTGTATTAGGAAAAAAA
GTTATCCATATTAAAAATGAAAGAGAAAAAATCAAACAAGCCATCGATTTGTTAATTGATGGATTTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9130.45 Da        Isoelectric Point: 9.9636

>AT101114 WP_068442587.1 NZ_CP028384:2826862-2827101 [Providencia heimbachae]
MSSTAHRMKKTVSVTVTPELYEQARRAKLNFSAILSNALIIELKKAEALKWKEQNREGFNELNRISDENGLLSDKYKEF

Download         Length: 240 bp

>AT101114 NZ_CP028384:2826862-2827101 [Providencia heimbachae]
ATGAGCTCTACAGCGCATAGAATGAAAAAAACCGTTAGTGTCACTGTGACACCTGAGTTATATGAACAAGCTAGACGCGC
TAAATTGAATTTCTCTGCTATTTTATCTAATGCTTTAATTATTGAGCTAAAAAAGGCTGAAGCATTAAAATGGAAAGAAC
AAAATAGAGAAGGTTTCAATGAGTTAAATAGAATAAGTGATGAAAATGGATTACTGTCCGATAAGTACAAGGAATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7K060

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7K057

References