Detailed information of TA system TA101113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2250215..2251134
• Replicon: chromosome
• Accession: NZ_CP028384
• Organism: Providencia heimbachae strain 99101

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: C9446_RS10065
• Protein ID: WP_137021662.1
• Coordinates: 2250676..2251134 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A1B7K397
• Locus tag: C9446_RS10060
• Protein ID: WP_068907217.1
• Coordinates: 2250215..2250679 (+)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9446_RS10025	2245790..2246404	+	615	WP_068443763.1	LysE family translocator	-
C9446_RS10030	2246415..2246879	-	465	WP_137021661.1	NUDIX domain-containing protein	-
C9446_RS10040	2247282..2247923	-	642	WP_068443749.1	leucine efflux protein LeuE	-
C9446_RS10045	2248421..2249122	+	702	WP_068443746.1	AzlC family ABC transporter permease	-
C9446_RS10050	2249119..2249433	+	315	WP_068907216.1	AzlD domain-containing protein	-
C9446_RS10055	2249654..2250133	+	480	WP_068443741.1	DUF1456 family protein	-
C9446_RS10060	2250215..2250679	+	465	WP_068907217.1	DUF2384 domain-containing protein	Antitoxin
C9446_RS10065	2250676..2251134	+	459	WP_137021662.1	RES domain-containing protein	Toxin
C9446_RS10070	2251135..2252025	-	891	WP_137021663.1	LysR family transcriptional regulator	-
C9446_RS10075	2252072..2253031	-	960	WP_068443729.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
C9446_RS10080	2253152..2253568	-	417	WP_068443727.1	helix-turn-helix domain-containing protein	-
C9446_RS10085	2253605..2254168	-	564	WP_068443724.1	GNAT family N-acetyltransferase	-
C9446_RS10090	2254149..2255615	-	1467	WP_175403111.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (100-151)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17208.66 Da
• Isoelectric Point: 6.4850

>T101113 WP_137021662.1 NZ_CP028384:2250676-2251134 [Providencia heimbachae]
MILYRLIKSDFAHDAWSGQGARLYGGRWNHKGTSAVYVSTQISLATLEILVHLNQERLLNHYNLFSIEISDKQVMKLPLE
HLPDDWQSDPAPTSTMDIGTAWLTDNASVALLIPSCVIPYEYNAIINPNHPQFTKVINSIKPLDFSFDARLK

Nucleotide

• Length: 459 bp

>T101113 NZ_CP028384:2250676-2251134 [Providencia heimbachae]
ATGATTTTATACCGGTTAATCAAATCTGATTTTGCACATGATGCATGGTCAGGGCAAGGTGCTCGATTATACGGTGGTCG
TTGGAATCATAAAGGAACCTCCGCAGTTTATGTCTCTACACAAATTTCTTTAGCTACTCTTGAAATACTAGTACACCTTA
ATCAAGAGCGCTTATTGAATCATTATAATTTATTTTCAATTGAAATCAGTGATAAACAAGTGATGAAGCTACCGTTAGAG
CATCTACCTGACGATTGGCAGAGTGATCCAGCCCCTACATCTACAATGGATATCGGCACCGCTTGGCTAACCGATAATGC
GAGTGTTGCACTACTGATCCCTTCTTGCGTGATCCCATATGAATATAATGCAATTATTAACCCGAACCATCCCCAATTTA
CTAAGGTAATCAATAGTATTAAACCGCTCGATTTTAGTTTTGATGCTCGGCTTAAATAA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17226.76 Da
• Isoelectric Point: 9.9134

>AT101113 WP_068907217.1 NZ_CP028384:2250215-2250679 [Providencia heimbachae]
MRNYIPTLPTSNIVSPTFKPLWRFAGLPAERGVELTHFLRQGLSVNVLDNIQEWSGMSKAELLRISGINERNFARRKNAG
QPLNTDESERIARLVRVFDAAVRLFNGDKVAANDWLNHPVKGLGHLRPIELIATESGALEVIDLIGRIEQGVFS

Nucleotide

• Length: 465 bp

>AT101113 NZ_CP028384:2250215-2250679 [Providencia heimbachae]
ATGAGAAATTATATTCCCACCCTTCCTACCTCAAATATTGTATCGCCTACATTCAAACCACTGTGGCGCTTTGCAGGTTT
GCCTGCAGAAAGAGGCGTTGAACTCACTCACTTTTTACGCCAAGGGCTATCGGTCAACGTATTGGACAATATCCAAGAAT
GGTCAGGAATGAGTAAAGCAGAATTACTTCGCATATCCGGTATTAACGAACGTAATTTTGCTCGGCGTAAAAATGCCGGT
CAGCCACTTAATACGGATGAAAGTGAACGAATTGCGCGTTTAGTTCGTGTTTTTGATGCTGCAGTACGACTATTTAACGG
TGATAAGGTTGCGGCCAACGACTGGTTAAATCATCCGGTAAAAGGCTTAGGACATCTTCGTCCTATTGAATTAATTGCGA
CAGAAAGCGGGGCATTAGAGGTTATAGACCTTATCGGGCGCATCGAACAGGGTGTCTTTTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1B7K397