Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1606417..1607064 Replicon chromosome
Accession NZ_CP028384
Organism Providencia heimbachae strain 99101

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C9446_RS07050 Protein ID WP_137021468.1
Coordinates 1606879..1607064 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C9446_RS07045 Protein ID WP_137021467.1
Coordinates 1606417..1606830 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9446_RS07020 1601742..1602875 - 1134 WP_068445218.1 M4 family metallopeptidase -
C9446_RS07025 1603034..1603951 - 918 WP_068445216.1 oxygen-dependent coproporphyrinogen oxidase -
C9446_RS07030 1604088..1604519 + 432 WP_137021465.1 GNAT family acetyltransferase -
C9446_RS07035 1604667..1605254 + 588 WP_068445212.1 RpoE-regulated lipoprotein -
C9446_RS07040 1605469..1606365 + 897 WP_137021466.1 Dyp-type peroxidase -
C9446_RS07045 1606417..1606830 - 414 WP_137021467.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C9446_RS07050 1606879..1607064 - 186 WP_137021468.1 type II toxin-antitoxin system HicA family toxin Toxin
C9446_RS07055 1607379..1608401 + 1023 WP_068910096.1 sulfate ABC transporter substrate-binding protein -
C9446_RS07060 1608401..1609231 + 831 WP_068445206.1 sulfate/thiosulfate ABC transporter permease CysT -
C9446_RS07065 1609231..1610091 + 861 WP_068445204.1 sulfate/thiosulfate ABC transporter permease CysW -
C9446_RS07070 1610094..1611182 + 1089 WP_137021469.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7024.30 Da        Isoelectric Point: 10.9659

>T101112 WP_137021468.1 NZ_CP028384:c1607064-1606879 [Providencia heimbachae]
MKSSELIRLLEKKGWKLERIKGSHHQFSHPDFSIVITVPHPNKDLKTGTLNQILKAAKLKH

Download         Length: 186 bp

>T101112 NZ_CP028384:c1607064-1606879 [Providencia heimbachae]
TTGAAAAGTTCGGAACTGATAAGGTTATTAGAAAAAAAAGGGTGGAAACTAGAGCGAATCAAAGGAAGTCATCATCAGTT
TTCTCATCCTGATTTTTCGATTGTTATCACAGTACCGCATCCTAATAAGGACTTGAAAACTGGAACGTTAAATCAAATCT
TAAAGGCAGCAAAACTGAAACATTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15307.12 Da        Isoelectric Point: 4.8029

>AT101112 WP_137021467.1 NZ_CP028384:c1606830-1606417 [Providencia heimbachae]
MLYPAFIEFDDNGSASGWFPDVEGCIFAGDNIEEAHADAKLAIDAHFELLSEKGFEIPMPKSQQAHLNSSSNEYGNGVWL
FVDIDMDKYDGRAERINITLPHRLLHRIDTLVKSNTEYGSRSAFIAAAARKELKKTS

Download         Length: 414 bp

>AT101112 NZ_CP028384:c1606830-1606417 [Providencia heimbachae]
ATGTTATACCCAGCATTTATTGAATTTGATGACAATGGTAGCGCAAGCGGCTGGTTTCCAGACGTCGAAGGGTGCATTTT
TGCTGGCGACAATATTGAAGAAGCACATGCAGATGCAAAATTAGCGATTGATGCCCACTTTGAGCTCCTAAGTGAAAAAG
GCTTTGAAATTCCAATGCCAAAATCTCAGCAAGCACATTTGAATTCTTCATCAAACGAATATGGTAATGGGGTATGGCTT
TTTGTTGATATTGATATGGATAAATATGATGGACGAGCAGAACGCATTAATATCACGCTACCACACCGTTTATTACACCG
TATTGACACACTCGTAAAATCAAATACAGAATACGGCAGCCGTAGCGCTTTTATTGCTGCGGCAGCACGCAAAGAACTAA
AAAAAACAAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References