Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1453206..1453863 Replicon chromosome
Accession NZ_CP028384
Organism Providencia heimbachae strain 99101

Toxin (Protein)


Gene name cptA Uniprot ID A0A1B7JKI9
Locus tag C9446_RS06375 Protein ID WP_068445594.1
Coordinates 1453453..1453863 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1B7JKJ9
Locus tag C9446_RS06370 Protein ID WP_068445596.1
Coordinates 1453206..1453472 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9446_RS06355 1448394..1451269 + 2876 Protein_1239 aminomethyl-transferring glycine dehydrogenase -
C9446_RS06360 1451336..1451956 - 621 WP_068445600.1 HD domain-containing protein -
C9446_RS06365 1451968..1452954 - 987 WP_068909907.1 tRNA-modifying protein YgfZ -
C9446_RS06370 1453206..1453472 + 267 WP_068445596.1 FAD assembly factor SdhE Antitoxin
C9446_RS06375 1453453..1453863 + 411 WP_068445594.1 hypothetical protein Toxin
C9446_RS06380 1453921..1454439 - 519 WP_068909908.1 flavodoxin FldB -
C9446_RS06385 1454579..1455481 + 903 WP_068445591.1 site-specific tyrosine recombinase XerD -
C9446_RS06390 1455501..1456202 + 702 WP_068909910.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C9446_RS06395 1456211..1457944 + 1734 WP_068909912.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15619.56 Da        Isoelectric Point: 10.7186

>T101110 WP_068445594.1 NZ_CP028384:1453453-1453863 [Providencia heimbachae]
VVLWKSNLAISWKTQLFSTCIHGVIGAFVLIAPWVSETSMIWLPLLVVIVASWAKSQKNISKIKGIVVLVNGNKVQWKKN
EWYIDKAPWRSRFGILLTLSALQGKPKKIHLWIAKDTVSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T101110 NZ_CP028384:1453453-1453863 [Providencia heimbachae]
GTGGTCCTGTGGAAATCTAATCTCGCCATTTCATGGAAAACTCAACTTTTTTCTACCTGTATTCATGGGGTAATAGGCGC
ATTTGTGCTAATTGCTCCGTGGGTATCAGAAACCTCTATGATTTGGCTGCCATTGCTGGTGGTGATTGTCGCGAGTTGGG
CGAAAAGCCAGAAAAATATCAGTAAAATTAAAGGGATCGTTGTTCTGGTTAACGGCAATAAAGTTCAGTGGAAGAAAAAT
GAGTGGTATATTGATAAAGCGCCTTGGCGCAGTCGATTTGGTATTTTGCTGACGCTAAGTGCCCTACAAGGCAAGCCGAA
AAAAATTCATTTGTGGATTGCGAAAGATACAGTTTCAGAAGAAAATTGGCGAAATTTAAATCAGCTATTACTGCAATATC
CAGATATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10542.03 Da        Isoelectric Point: 4.6786

>AT101110 WP_068445596.1 NZ_CP028384:1453206-1453472 [Providencia heimbachae]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDGLSSEDKQTFVNLLECADPDLFNWLMNHGRPDDDKLFYMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT101110 NZ_CP028384:1453206-1453472 [Providencia heimbachae]
ATGGATATAGAGAATAAAGCGCGAATTCATTGGGCTTGTAGACGTGGTATGCGTGAATTGGATATTTCAATCATGCCTTT
TTTTGAATATGAGTATGATGGTTTATCGAGTGAAGACAAGCAGACGTTTGTGAATCTGTTGGAATGTGCTGATCCAGACT
TATTCAACTGGTTAATGAATCATGGTCGTCCAGATGACGATAAATTATTTTATATGGTAAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JKI9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JKJ9

References