Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 858283..858925 Replicon chromosome
Accession NZ_CP028384
Organism Providencia heimbachae strain 99101

Toxin (Protein)


Gene name Hha Uniprot ID A0A1B7JP77
Locus tag C9446_RS03680 Protein ID WP_068439370.1
Coordinates 858283..858486 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1B7JPC0
Locus tag C9446_RS03685 Protein ID WP_068439372.1
Coordinates 858557..858925 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9446_RS03655 854248..854586 + 339 WP_068909458.1 P-II family nitrogen regulator -
C9446_RS03660 854597..855880 + 1284 WP_137021250.1 ammonium transporter AmtB -
C9446_RS03665 855995..856861 - 867 WP_068909460.1 acyl-CoA thioesterase II -
C9446_RS03670 857182..857640 + 459 WP_068439368.1 YbaY family lipoprotein -
C9446_RS03680 858283..858486 - 204 WP_068439370.1 hemolysin expression modulator Hha Toxin
C9446_RS03685 858557..858925 - 369 WP_068439372.1 Hha toxicity modulator TomB Antitoxin
C9446_RS03690 859322..860353 - 1032 WP_137021093.1 IS630 family transposase -
C9446_RS03695 860725..862095 - 1371 WP_137021251.1 murein transglycosylase D -
C9446_RS03700 862177..862932 - 756 WP_068439376.1 hydroxyacylglutathione hydrolase -
C9446_RS03705 862966..863694 + 729 WP_068439378.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 859322..860353 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.50 Da        Isoelectric Point: 6.9775

>T101108 WP_068439370.1 NZ_CP028384:c858486-858283 [Providencia heimbachae]
MTKFDYLMRLRKCTTIETLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T101108 NZ_CP028384:c858486-858283 [Providencia heimbachae]
ATGACCAAATTTGATTATCTAATGCGTTTAAGAAAATGCACAACAATTGAAACACTTGAGCGTGTCATTGAAAAAAATAA
GTACGAGCTCTCTGAAGATGAGCTGGAGTTATTTTACTCAGCTGCTGATCATCGCCTAGCTGAGCTGACAATGAATAAAC
TTTACGACAAGATACCACCATCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14181.08 Da        Isoelectric Point: 4.3945

>AT101108 WP_068439372.1 NZ_CP028384:c858925-858557 [Providencia heimbachae]
MDEYSPKKHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSQQSANLNELIEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWESMNQNLVSVLEDDLKCLTSKT

Download         Length: 369 bp

>AT101108 NZ_CP028384:c858925-858557 [Providencia heimbachae]
ATGGATGAATATTCACCCAAAAAACATGATATAGCAGAGTTAAAGTATTTATGTAACAGTCTGAATCGAGACGCAATTTT
AAGTTTACAAAAAACGAATACACACTGGATAAATGATCTCAGCTCACAACAAAGTGCCAATCTCAATGAACTTATCGAGC
ATATTGCTGCTTTTGTTTGGCGATTTAAAATTAAATATCCAAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GACGAGACCTATGACTTATTCGGTAGCCCTGTAATAACGCTTAGTGAGATTATTGACTGGGAAAGCATGAACCAAAATCT
TGTCTCTGTTCTGGAAGATGATTTAAAATGTCTGACCAGTAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JP77

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JPC0

References