Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1302622..1303417 Replicon chromosome
Accession NZ_CP028379
Organism Escherichia coli O145 str. RM9872

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag I3Y_RS06480 Protein ID WP_000854914.1
Coordinates 1303043..1303417 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag I3Y_RS06475 Protein ID WP_001280953.1
Coordinates 1302622..1302996 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3Y_RS06435 1297977..1298882 + 906 WP_000203541.1 chemotaxis protein -
I3Y_RS06440 1298879..1299949 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
I3Y_RS06455 1300289..1301107 + 819 WP_001234682.1 DUF945 domain-containing protein -
I3Y_RS06460 1301198..1301683 + 486 WP_000214398.1 antirestriction protein -
I3Y_RS06465 1301699..1302175 + 477 WP_001186738.1 RadC family protein -
I3Y_RS06470 1302238..1302459 + 222 WP_000692323.1 DUF987 domain-containing protein -
I3Y_RS06475 1302622..1302996 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I3Y_RS06480 1303043..1303417 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
I3Y_RS06485 1303414..1303905 + 492 WP_000976857.1 hypothetical protein -
I3Y_RS06490 1303917..1304114 + 198 WP_000839282.1 DUF957 domain-containing protein -
I3Y_RS06495 1304199..1305041 + 843 WP_001280481.1 DUF4942 domain-containing protein -
I3Y_RS06505 1305512..1306450 + 939 WP_000351301.1 glyoxylate/hydroxypyruvate reductase GhrA -
I3Y_RS06510 1306505..1307242 + 738 WP_000283664.1 zinc-binding phosphatase -
I3Y_RS06515 1307266..1307820 + 555 WP_001001917.1 molecular chaperone YcdY -
I3Y_RS06520 1307922..1308413 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T101052 WP_000854914.1 NZ_CP028379:1303043-1303417 [Escherichia coli O145 str. RM9872]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T101052 NZ_CP028379:1303043-1303417 [Escherichia coli O145 str. RM9872]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT101052 WP_001280953.1 NZ_CP028379:1302622-1302996 [Escherichia coli O145 str. RM9872]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT101052 NZ_CP028379:1302622-1302996 [Escherichia coli O145 str. RM9872]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References