Detailed information of TA system TA101047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3407650..3408214
• Replicon: chromosome
• Accession: NZ_CP028369
• Organism: Streptomyces sp. P3

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: C6376_RS15275
• Protein ID: WP_173985893.1
• Coordinates: 3407864..3408214 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: C6376_RS15270
• Protein ID: WP_107443922.1
• Coordinates: 3407650..3407880 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6376_RS15255	3403259..3403795	-	537	WP_107443919.1	MarR family transcriptional regulator	-
C6376_RS15260	3403904..3404854	+	951	WP_173985647.1	EamA family transporter	-
C6376_RS15265	3404982..3407549	-	2568	WP_107443921.1	aminopeptidase N	-
C6376_RS15270	3407650..3407880	+	231	WP_107443922.1	ribbon-helix-helix domain-containing protein	Antitoxin
C6376_RS15275	3407864..3408214	+	351	WP_173985893.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
C6376_RS15280	3408275..3409291	-	1017	WP_107443924.1	aspartate-semialdehyde dehydrogenase	-
C6376_RS15285	3409607..3410149	+	543	WP_107443925.1	sigma-70 family RNA polymerase sigma factor	-
C6376_RS15290	3410151..3410996	+	846	WP_107443926.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12847.77 Da
• Isoelectric Point: 10.2970

>T101047 WP_173985893.1 NZ_CP028369:3407864-3408214 [Streptomyces sp. P3]
MMRRGDIYLVDYEPTRGSEGNKARPSVIVSNDAANRSVERHGRGVITVVPLTSNTTRVLTFQVFLGADECHLPKDSKAQC
EQVRAVTPERILARIGAVPRPRMAEIDGALRRHLAL

Nucleotide

• Length: 351 bp

>T101047 NZ_CP028369:3407864-3408214 [Streptomyces sp. P3]
CTGATGAGACGCGGTGACATCTATCTGGTCGACTACGAGCCGACGCGAGGCAGCGAAGGGAACAAGGCGCGCCCCTCGGT
GATCGTCTCCAACGACGCCGCCAACCGGTCGGTCGAGCGCCACGGCCGAGGGGTGATCACCGTGGTGCCCCTCACGTCGA
ACACGACGCGCGTCCTGACGTTCCAGGTGTTCCTCGGCGCGGACGAGTGCCACTTGCCCAAGGACTCGAAGGCTCAGTGC
GAGCAGGTTCGAGCCGTGACTCCGGAGCGGATCCTTGCGCGGATCGGTGCGGTGCCACGACCGCGCATGGCGGAGATCGA
CGGCGCACTCAGGCGGCACCTCGCTCTCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8470.12 Da
• Isoelectric Point: 3.8057

>AT101047 WP_107443922.1 NZ_CP028369:3407650-3407880 [Streptomyces sp. P3]
MKISVSLPQEDVAFVDEYASRTEADSRSAVIHAAIELLRADQLEAEYAEAFQEWDGSEDAGFWDRFAGDGLADETR

Nucleotide

• Length: 231 bp

>AT101047 NZ_CP028369:3407650-3407880 [Streptomyces sp. P3]
ATGAAGATCAGTGTGAGCCTGCCGCAGGAGGACGTCGCCTTCGTCGACGAGTACGCGTCCAGAACCGAGGCCGATTCGCG
GTCCGCCGTGATACACGCTGCCATCGAACTGCTGCGTGCCGATCAGCTGGAGGCCGAGTACGCCGAGGCATTCCAGGAAT
GGGACGGGAGCGAGGACGCCGGGTTCTGGGACAGGTTCGCGGGCGACGGGCTGGCTGATGAGACGCGGTGA