Detailed information of TA system TA101046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2537783..2538326
• Replicon: chromosome
• Accession: NZ_CP028369
• Organism: Streptomyces sp. P3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C6376_RS11425
• Protein ID: WP_107443313.1
• Coordinates: 2537783..2538064 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C6376_RS11430
• Protein ID: WP_173985881.1
• Coordinates: 2538069..2538326 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6376_RS11395	2534018..2534779	+	762	WP_107443310.1	phosphoglyceromutase	-
C6376_RS11420	2536905..2537312	+	408	WP_107443312.1	NUDIX domain-containing protein	-
C6376_RS11425	2537783..2538064	-	282	WP_107443313.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6376_RS11430	2538069..2538326	-	258	WP_173985881.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C6376_RS11435	2538707..2539033	-	327	Protein_2203	hypothetical protein	-
C6376_RS11440	2538984..2539439	+	456	WP_107443315.1	helicase-associated domain-containing protein	-
C6376_RS11445	2539812..2540417	-	606	WP_107443316.1	dihydrofolate reductase family protein	-
C6376_RS11450	2540953..2541423	-	471	WP_107443317.1	hypothetical protein	-
C6376_RS11455	2541454..2543229	-	1776	WP_107443318.1	FAD-dependent monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-62)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10698.42 Da
• Isoelectric Point: 10.7805

>T101046 WP_107443313.1 NZ_CP028369:c2538064-2537783 [Streptomyces sp. P3]
MGYVTRFTPHAQRDMLKIPRPDALRILYRLTELQKALDAGGAASFDVKVLQGHSARWRLRVGDYRVVYTVEDGQLIVWVL
AVGNRRDIHRQVP

Nucleotide

• Length: 282 bp

>T101046 NZ_CP028369:c2538064-2537783 [Streptomyces sp. P3]
ATGGGGTACGTCACGCGCTTCACGCCGCACGCTCAGCGGGACATGCTCAAGATCCCGCGCCCGGACGCCCTGCGCATCCT
GTACCGCCTCACCGAACTCCAGAAGGCGCTGGACGCCGGGGGCGCCGCCTCCTTCGACGTCAAGGTCCTCCAGGGGCACA
GCGCCCGCTGGCGGCTCAGGGTCGGCGACTACCGCGTCGTCTACACCGTCGAGGACGGTCAGCTGATCGTGTGGGTCCTG
GCCGTCGGCAATCGCCGCGACATCCACCGCCAAGTTCCATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9578.59 Da
• Isoelectric Point: 4.2800

>AT101046 WP_173985881.1 NZ_CP028369:c2538326-2538069 [Streptomyces sp. P3]
MADVRSHLADVIDRARREDTPTIITRRGKQEAVVIDIQEYQRLREIAENTEEAWLNRLADEAESEGAQGSVSLEEMAALL
RADQG

Nucleotide

• Length: 258 bp

>AT101046 NZ_CP028369:c2538326-2538069 [Streptomyces sp. P3]
ATGGCGGATGTCCGCAGCCACCTCGCTGACGTCATCGATCGAGCCCGCCGGGAGGACACCCCGACGATCATCACTCGGCG
GGGCAAGCAGGAAGCCGTCGTGATCGACATCCAGGAGTACCAGCGCCTACGTGAGATCGCGGAGAACACCGAAGAGGCGT
GGCTCAACCGACTTGCCGACGAAGCCGAGTCCGAGGGTGCGCAGGGGTCGGTCTCGCTCGAAGAGATGGCCGCCTTGCTA
CGTGCCGATCAGGGCTGA