Detailed information of TA system TA101045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1877630..1878158
• Replicon: chromosome
• Accession: NZ_CP028369
• Organism: Streptomyces sp. P3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C6376_RS08385
• Protein ID: WP_107442841.1
• Coordinates: 1877898..1878158 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C6376_RS08380
• Protein ID: WP_103544659.1
• Coordinates: 1877630..1877887 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6376_RS08355	1873608..1874144	-	537	WP_107442837.1	DUF2617 family protein	-
C6376_RS08360	1874521..1874850	-	330	WP_107442838.1	hypothetical protein	-
C6376_RS08365	1874991..1876187	+	1197	WP_107442839.1	pyridoxal phosphate-dependent aminotransferase	-
C6376_RS08370	1876350..1876904	-	555	WP_107442840.1	Uma2 family endonuclease	-
C6376_RS08375	1877031..1877471	+	441	Protein_1623	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
C6376_RS08380	1877630..1877887	+	258	WP_103544659.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C6376_RS08385	1877898..1878158	+	261	WP_107442841.1	Txe/YoeB family addiction module toxin	Toxin
C6376_RS43740	1878231..1878788	-	558	WP_159083180.1	hypothetical protein	-
C6376_RS08390	1878928..1880340	-	1413	WP_159083181.1	plasmid pRiA4b ORF-3 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10333.71 Da
• Isoelectric Point: 9.4253

>T101045 WP_107442841.1 NZ_CP028369:1877898-1878158 [Streptomyces sp. P3]
MKITFSSRAWEDYLWWQHQDRKILKRINTLIADIARNGNEGIGKPEPLKHGFQGYWSRRINDEHRLIYKATEDGVLIAQC
RYHYES

Nucleotide

• Length: 261 bp

>T101045 NZ_CP028369:1877898-1878158 [Streptomyces sp. P3]
TTGAAGATCACCTTCTCCTCCCGTGCCTGGGAGGACTATCTGTGGTGGCAGCATCAGGACCGGAAGATCCTGAAGCGCAT
CAACACGCTCATCGCGGACATCGCCCGGAACGGCAACGAGGGGATCGGCAAACCGGAACCGCTCAAACACGGATTCCAGG
GCTACTGGTCGCGCCGTATCAACGACGAGCACCGGCTGATCTACAAGGCCACCGAGGACGGCGTCCTGATCGCACAGTGC
CGCTACCACTACGAGAGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9443.48 Da
• Isoelectric Point: 4.3246

>AT101045 WP_103544659.1 NZ_CP028369:1877630-1877887 [Streptomyces sp. P3]
VKTMTYSESRARYAEVLNSVTDDREEVVITRAGHEPVVIVSLEDYESLKETAYLLRSPANARRLLASIDELESGGGTVRE
LATDE

Nucleotide

• Length: 258 bp

>AT101045 NZ_CP028369:1877630-1877887 [Streptomyces sp. P3]
GTGAAGACCATGACCTATTCCGAGTCGCGCGCGCGGTACGCCGAGGTGCTCAACTCCGTCACCGACGACCGCGAAGAGGT
CGTCATCACCCGGGCCGGACATGAGCCGGTCGTCATAGTCTCCCTTGAGGACTACGAGTCCCTGAAAGAGACGGCGTACC
TGCTGCGGAGCCCGGCCAACGCGCGGCGCCTGCTCGCGTCCATCGACGAGTTGGAAAGCGGCGGCGGCACCGTACGCGAG
CTGGCGACCGACGAATAA