Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 638876..639463 Replicon chromosome
Accession NZ_CP028369
Organism Streptomyces sp. P3

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C6376_RS02640 Protein ID WP_107441909.1
Coordinates 639086..639463 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C6376_RS02635 Protein ID WP_107448734.1
Coordinates 638876..639073 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6376_RS02610 635250..635672 - 423 WP_107441908.1 hypothetical protein -
C6376_RS02620 636443..637279 + 837 WP_107448733.1 IS5 family transposase -
C6376_RS02625 637299..637763 - 465 Protein_505 hypothetical protein -
C6376_RS02630 637921..638738 + 818 WP_107441902.1 IS5 family transposase -
C6376_RS02635 638876..639073 + 198 WP_107448734.1 hypothetical protein Antitoxin
C6376_RS02640 639086..639463 + 378 WP_107441909.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
C6376_RS02645 639661..640056 - 396 Protein_509 hypothetical protein -
C6376_RS02650 640179..640990 + 812 Protein_510 transposase -
C6376_RS02655 641298..642038 + 741 WP_107441910.1 hypothetical protein -
C6376_RS02660 642432..642911 - 480 WP_107441911.1 hypothetical protein -
C6376_RS02670 643344..643727 - 384 WP_107441912.1 hypothetical protein -
C6376_RS02680 643936..644238 - 303 WP_107448735.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 622163..642911 20748
- flank IS/Tn - - 634541..634759 218
- flank IS/Tn - - 640179..640547 368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13478.14 Da        Isoelectric Point: 4.6485

>T101043 WP_107441909.1 NZ_CP028369:639086-639463 [Streptomyces sp. P3]
ITEYLDANDVIQIAEITLGGRVGVRDWGLLQSAVARPQASVFGEDAYPTLFDKAAALLHSVSSNHSLVDGNKRTGWASAA
VFLHINGHPLKEPLDEDAAEEFVLAVAQSQLSNPEIANRLRLFVA

Download         Length: 378 bp

>T101043 NZ_CP028369:639086-639463 [Streptomyces sp. P3]
ATAACCGAGTACCTGGACGCCAATGACGTCATCCAGATCGCGGAAATCACTCTTGGTGGCCGTGTTGGCGTACGCGATTG
GGGGCTGTTGCAAAGCGCCGTCGCTCGCCCTCAGGCCAGCGTGTTCGGCGAGGATGCCTACCCAACGCTCTTCGACAAGG
CAGCAGCTCTGCTGCACTCTGTCTCCAGCAATCACAGCCTGGTAGACGGGAACAAGCGCACTGGGTGGGCATCAGCCGCC
GTCTTCCTACACATCAACGGGCATCCGCTGAAGGAACCCCTGGACGAGGACGCGGCTGAGGAGTTCGTGTTGGCAGTGGC
TCAGTCTCAGTTGTCGAACCCGGAGATCGCCAACCGCTTGAGGCTATTCGTTGCTTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7092.14 Da        Isoelectric Point: 8.8776

>AT101043 WP_107448734.1 NZ_CP028369:638876-639073 [Streptomyces sp. P3]
MPALNVTFTDDEMATLRDQAAKEDVSMKTLAHDAVLAEVHRRKVTAAAIRTARISAGLNERLATK

Download         Length: 198 bp

>AT101043 NZ_CP028369:638876-639073 [Streptomyces sp. P3]
ATGCCTGCACTGAACGTCACTTTCACTGACGACGAGATGGCCACGCTCCGCGACCAGGCAGCGAAGGAGGATGTCAGCAT
GAAGACACTGGCGCACGATGCCGTCTTGGCTGAGGTCCACCGACGCAAGGTGACCGCTGCCGCCATCAGGACTGCCCGTA
TCTCCGCAGGCCTGAACGAGCGCCTCGCCACTAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References