Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/couple_hipB(antitoxin)
Location 3513194..3514350 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag Tharo_RS16515 Protein ID WP_211309629.1
Coordinates 3513445..3514350 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag Tharo_RS16510 Protein ID WP_211309628.1
Coordinates 3513194..3513439 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS16495 3508938..3509885 + 948 WP_107222142.1 SDR family oxidoreductase -
Tharo_RS16500 3509886..3510911 + 1026 WP_107222143.1 glycosyltransferase family 4 protein -
Tharo_RS16505 3511100..3513031 + 1932 WP_107222144.1 polysaccharide biosynthesis protein -
Tharo_RS16510 3513194..3513439 + 246 WP_211309628.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
Tharo_RS16515 3513445..3514350 + 906 WP_211309629.1 HipA N-terminal domain-containing protein Toxin
Tharo_RS16520 3514515..3515567 - 1053 WP_107222146.1 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase -
Tharo_RS16525 3515692..3516066 + 375 WP_107222147.1 divalent-cation tolerance protein CutA -
Tharo_RS16530 3516087..3517922 + 1836 WP_211309700.1 protein-disulfide reductase DsbD -
Tharo_RS16535 3517978..3518592 + 615 WP_107222149.1 riboflavin synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 32970.60 Da        Isoelectric Point: 6.9460

>T101004 WP_211309629.1 NZ_CP028339:3513445-3514350 [Thauera aromatica K172]
MARELDVWLFADRIGTLSLVEGRLGFRYSTDWLSRSDAVALSSSLPLRAEPFDDHHTRPFFGGLLPEGQLRRLIAQQFQV
SSQNDFALLDRIGGECAGAVTLLEPGQAIPTLEQGADVQWLGDEEIVAILDELPHRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPRNGTPSSHILKPAIRTLADTVTNEGFCLALAGAMQLKPARSQVRSVLDRPFLLVERYDRVANAQGQRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLGPVRCSSWPGQSRCRRLRGNSSPTPSVASPAMLWLSKS

Download         Length: 906 bp

>T101004 NZ_CP028339:3513445-3514350 [Thauera aromatica K172]
ATGGCACGTGAACTGGATGTATGGCTGTTCGCTGACCGAATCGGCACCCTGAGCCTGGTGGAGGGCCGGCTGGGTTTCCG
TTACAGCACGGATTGGCTCTCACGTTCAGACGCGGTGGCCTTGTCCAGTTCCCTGCCGCTGCGAGCAGAGCCATTCGACG
ATCACCACACTCGCCCCTTCTTTGGGGGGCTGTTGCCAGAGGGGCAACTCCGGCGCCTCATTGCACAGCAGTTTCAGGTA
TCGAGCCAGAATGACTTTGCGCTGCTCGATCGCATCGGCGGGGAGTGTGCCGGCGCCGTGACCTTGCTGGAGCCAGGGCA
GGCGATCCCCACTCTTGAGCAAGGCGCCGACGTTCAGTGGCTGGGCGACGAAGAGATCGTCGCCATTCTCGATGAACTGC
CGCATCGGCCGATGTTGGCCGGCAAGGATGGCCTGCGGCTTTCACTGGCGGGCGCTCAAGACAAATTGCCGGTGGTTTTC
GATGGCGCCCGGATCGGGCTGCCGCGAAACGGAACGCCCAGCTCACATATCTTGAAGCCAGCCATCCGTACCCTGGCGGA
CACCGTCACCAACGAAGGCTTCTGCCTGGCGTTGGCCGGGGCGATGCAGCTCAAGCCGGCCAGGTCACAGGTGCGTTCCG
TGTTGGACCGACCGTTCCTGCTGGTCGAGCGCTACGACCGGGTGGCCAATGCACAAGGCCAGCGGCAGCGCCTGCACCAG
GAGGATTTTTGCCAGGCGCTGGGCGTGGTGCCGGAAATGAAATACCAGAACGAAGGTGGCCCGGACCTAGGACCAGTTCG
CTGCAGCAGCTGGCCTGGGCAAAGTCGATGCCGCCGGCTGCGGGGAAACTCCAGTCCGACCCCGAGTGTGGCTTCACCGG
CCATGTTGTGGTTGAGCAAATCGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8458.81 Da        Isoelectric Point: 8.9835

>AT101004 WP_211309628.1 NZ_CP028339:3513194-3513439 [Thauera aromatica K172]
VMGSIRTTEQLGNALRAARKQLGLTQPQLALSAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEIQLTGLPSTPAVNPE
G

Download         Length: 246 bp

>AT101004 NZ_CP028339:3513194-3513439 [Thauera aromatica K172]
GTGATGGGCTCCATACGGACTACGGAACAACTCGGTAACGCACTCCGTGCTGCACGCAAGCAGCTGGGCCTGACGCAGCC
CCAGTTGGCGTTGTCGGCAGGGGTTGGGGTTCGCTTCATCGTCGACCTTGAAGCGGGCAAGCCGACGCTGCGTCTGGAAA
ATGTGCTGCGCGTGATCGACGCCTTGGGCGGAGAGATCCAACTCACCGGCTTGCCATCGACCCCGGCGGTAAATCCGGAG
GGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References