Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 3473001..3473478 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag Tharo_RS16320 Protein ID WP_107222115.1
Coordinates 3473001..3473267 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag Tharo_RS16325 Protein ID WP_107222116.1
Coordinates 3473251..3473478 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS16290 3468281..3468874 + 594 WP_107222109.1 Uma2 family endonuclease -
Tharo_RS16295 3468871..3469917 + 1047 WP_107222110.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
Tharo_RS16300 3469939..3470718 + 780 WP_107222111.1 adenosylcobinamide-GDP ribazoletransferase -
Tharo_RS16305 3470743..3471057 - 315 WP_107222112.1 type II toxin-antitoxin system RelE/ParE family toxin -
Tharo_RS16310 3471062..3471298 - 237 WP_211309627.1 addiction module antitoxin -
Tharo_RS16315 3471640..3472827 + 1188 WP_107222114.1 ATP-binding protein -
Tharo_RS16320 3473001..3473267 - 267 WP_107222115.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Tharo_RS16325 3473251..3473478 - 228 WP_107222116.1 ribbon-helix-helix protein, CopG family Antitoxin
Tharo_RS16330 3473507..3474139 - 633 WP_107222117.1 putative addiction module antidote protein -
Tharo_RS16335 3474505..3475827 + 1323 WP_107222118.1 ISL3 family transposase -
Tharo_RS17610 3475832..3476350 - 519 WP_159051725.1 hypothetical protein -
Tharo_RS16340 3476465..3476878 - 414 Protein_3194 IS1595 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(5-44)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 9859.41 Da        Isoelectric Point: 9.5129

>T101003 WP_107222115.1 NZ_CP028339:c3473267-3473001 [Thauera aromatica K172]
MAWMIDYTDTALKQLRGLDKPTARRILDYLDGRVVGSGDPCSAGKALTGPLGGLWRYRVGDYRVICDLQDGRMRVLVVQL
GNRGEVYR

Download         Length: 267 bp

>T101003 NZ_CP028339:c3473267-3473001 [Thauera aromatica K172]
TTGGCCTGGATGATTGATTACACCGACACCGCGCTCAAGCAGTTGCGCGGACTGGACAAGCCCACGGCCCGTCGCATCCT
CGACTACCTCGACGGTCGGGTGGTCGGCAGCGGCGACCCGTGCAGCGCCGGCAAGGCGCTTACCGGCCCGCTGGGTGGGT
TGTGGCGTTATCGGGTGGGTGATTACCGAGTGATCTGCGATCTGCAAGACGGCCGGATGCGGGTGCTGGTCGTGCAACTT
GGCAACCGGGGCGAGGTTTACCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8567.61 Da        Isoelectric Point: 4.3525

>AT101003 WP_107222116.1 NZ_CP028339:c3473478-3473251 [Thauera aromatica K172]
MPTSIRLDTEIERRLDLLATTTGRSKAFYLRQIIEQGIEDMEDYYLSADVLERVRKGQEPVHSAADVRADLGLDD

Download         Length: 228 bp

>AT101003 NZ_CP028339:c3473478-3473251 [Thauera aromatica K172]
ATGCCTACTTCCATCCGACTTGATACCGAGATCGAGCGTCGGCTTGATCTGCTTGCTACCACCACCGGCCGCAGCAAGGC
GTTCTACCTGCGGCAGATCATCGAGCAGGGCATCGAGGACATGGAGGATTACTACCTCTCCGCCGATGTGCTCGAACGTG
TGCGCAAGGGTCAGGAGCCGGTGCACTCCGCCGCTGACGTGAGGGCGGATCTTGGCCTGGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References