Detailed information of TA system TA101002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 3312408..3312910
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2R4BRX9
• Locus tag: Tharo_RS15575
• Protein ID: WP_075147756.1
• Coordinates: 3312656..3312910 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Tharo_RS15570
• Protein ID: WP_107221990.1
• Coordinates: 3312408..3312659 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS15550	3308253..3308837	+	585	WP_107221986.1	YgiT-type zinc finger protein	-
Tharo_RS15555	3308834..3309757	+	924	WP_107221987.1	DUF4037 domain-containing protein	-
Tharo_RS15560	3309780..3310724	+	945	WP_107221988.1	SDR family oxidoreductase	-
Tharo_RS15565	3310721..3312292	+	1572	WP_107221989.1	amidohydrolase	-
Tharo_RS15570	3312408..3312659	+	252	WP_107221990.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Tharo_RS15575	3312656..3312910	+	255	WP_075147756.1	Txe/YoeB family addiction module toxin	Toxin
Tharo_RS15580	3313058..3313687	-	630	WP_075147755.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
Tharo_RS15585	3313755..3314525	-	771	WP_075147754.1	enoyl-CoA hydratase/isomerase family protein	-
Tharo_RS15590	3314564..3315784	-	1221	WP_075147753.1	acyl-CoA dehydrogenase	-
Tharo_RS15595	3315903..3317132	-	1230	WP_075147752.1	CoA transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10166.73 Da
• Isoelectric Point: 9.8954

>T101002 WP_075147756.1 NZ_CP028339:3312656-3312910 [Thauera aromatica K172]
MKLIFAEAAWEDYLHWQQQDRRMVERINKLIRETQREPFSGIGKPEPLKHALAGFWSRRITDEHRMVYRIAGDALLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T101002 NZ_CP028339:3312656-3312910 [Thauera aromatica K172]
ATGAAGTTGATCTTCGCCGAGGCCGCTTGGGAAGATTACCTTCATTGGCAGCAACAAGACCGACGCATGGTGGAGCGGAT
CAACAAGCTCATTCGCGAAACGCAGCGTGAACCTTTTTCCGGTATCGGCAAACCTGAACCGCTCAAACACGCCCTGGCGG
GATTTTGGTCCAGGCGGATTACCGACGAGCATCGGATGGTGTACAGAATCGCCGGCGACGCGTTGCTGATCGCTCAGTTG
CGCTACCATTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9010.07 Da
• Isoelectric Point: 4.2404

>AT101002 WP_107221990.1 NZ_CP028339:3312408-3312659 [Thauera aromatica K172]
MDAISYTAARANLASTMDRVCNNHEPLIITRSGQASVVMVSLDDFQALEETAYLLRSPKNATRLLDAIAELNAGGGNERE
LDE

Nucleotide

• Length: 252 bp

>AT101002 NZ_CP028339:3312408-3312659 [Thauera aromatica K172]
ATGGACGCCATTTCCTACACCGCAGCCCGGGCCAATCTGGCCAGTACGATGGACCGCGTCTGCAACAACCACGAGCCGCT
GATCATTACCCGTAGCGGGCAAGCCTCGGTCGTCATGGTTTCCCTCGACGACTTCCAGGCCCTCGAGGAAACCGCCTACC
TGTTGCGTAGCCCCAAGAATGCGACCCGCCTGCTCGACGCCATAGCCGAACTCAATGCCGGCGGAGGCAACGAGCGGGAA
CTCGACGAATGA

Structures

Toxin

• AlphaFold DB: A0A2R4BRX9