Detailed information of TA system TA101001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3052652..3053205
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Tharo_RS14450
• Protein ID: WP_107221798.1
• Coordinates: 3052912..3053205 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Tharo_RS14445
• Protein ID: WP_107221797.1
• Coordinates: 3052652..3052924 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS17605	3049174..3049497	+	324	WP_159051711.1	DUF3325 family protein	-
Tharo_RS14435	3049587..3050015	+	429	WP_107221796.1	heavy-metal-associated domain-containing protein	-
Tharo_RS14440	3050100..3052214	-	2115	WP_211309621.1	TonB-dependent siderophore receptor	-
Tharo_RS14445	3052652..3052924	+	273	WP_107221797.1	CopG family ribbon-helix-helix protein	Antitoxin
Tharo_RS14450	3052912..3053205	+	294	WP_107221798.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Tharo_RS14455	3053304..3055448	-	2145	WP_107221799.1	heavy metal translocating P-type ATPase	-
Tharo_RS14460	3055445..3055786	-	342	WP_107221800.1	hypothetical protein	-
Tharo_RS14465	3055779..3056078	-	300	WP_107222449.1	hypothetical protein	-
Tharo_RS14470	3056108..3056446	-	339	WP_107221801.1	hypothetical protein	-
Tharo_RS14475	3056592..3056933	-	342	WP_107222450.1	heavy-metal-associated domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10750.30 Da
• Isoelectric Point: 5.8498

>T101001 WP_107221798.1 NZ_CP028339:3052912-3053205 [Thauera aromatica K172]
VPQVIVTEGAAESLERCRRLLAAKAPEAARRAGQAIERQFLLLQTAPDIGRPFPEMPGLRELVIAFGDSGYVALYRYEAT
DDAVYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T101001 NZ_CP028339:3052912-3053205 [Thauera aromatica K172]
GTGCCACAAGTAATCGTCACTGAAGGCGCAGCGGAAAGCTTGGAACGATGCCGGCGGCTCCTTGCCGCCAAGGCCCCGGA
AGCCGCCAGGCGGGCCGGCCAGGCCATTGAGCGGCAATTCCTGCTGCTGCAAACGGCTCCCGACATTGGCCGGCCGTTCC
CTGAAATGCCCGGGCTGCGTGAGCTGGTGATTGCCTTCGGGGACTCCGGCTATGTAGCCCTGTACCGCTACGAGGCGACC
GACGATGCGGTGTATGTTCTGGCCTTCCGACACCAGAAAGAGGCGGGCTACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10575.83 Da
• Isoelectric Point: 8.0869

>AT101001 WP_107221797.1 NZ_CP028339:3052652-3052924 [Thauera aromatica K172]
MATSLKIDDKLKSRVQHLASQRRRSPHRIMLEAIQQYVEREEARESFKQEALASWAAYQETGRHLSGQEVRTWLNTWGTD
DERPAPECHK

Nucleotide

• Length: 273 bp

>AT101001 NZ_CP028339:3052652-3052924 [Thauera aromatica K172]
ATGGCAACGTCCCTCAAGATCGACGACAAGCTGAAAAGCCGCGTCCAGCACCTCGCCAGCCAGCGTCGCCGCTCGCCCCA
CAGGATCATGCTCGAAGCCATCCAGCAGTACGTCGAGCGCGAGGAAGCCCGCGAGAGCTTCAAGCAGGAAGCTTTGGCAT
CCTGGGCGGCCTATCAGGAAACCGGCCGGCACCTGAGCGGACAGGAAGTGCGCACTTGGTTGAACACCTGGGGCACCGAT
GACGAAAGGCCGGCGCCCGAGTGCCACAAGTAA