Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2156767..2157332 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Tharo_RS10220 Protein ID WP_107221088.1
Coordinates 2156991..2157332 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Tharo_RS10215 Protein ID WP_107221087.1
Coordinates 2156767..2156994 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS10180 2151884..2152726 + 843 WP_107222392.1 ABC transporter permease -
Tharo_RS10185 2152770..2153582 + 813 WP_107221081.1 phosphonate ABC transporter, permease protein PhnE -
Tharo_RS10190 2153739..2153930 + 192 WP_107221082.1 hypothetical protein -
Tharo_RS10195 2154031..2155338 - 1308 WP_107221083.1 HipA domain-containing protein -
Tharo_RS10200 2155335..2155601 - 267 WP_107221084.1 helix-turn-helix transcriptional regulator -
Tharo_RS10205 2155895..2156116 + 222 WP_107221085.1 hypothetical protein -
Tharo_RS10210 2156094..2156378 + 285 WP_107221086.1 helix-turn-helix domain-containing protein -
Tharo_RS10215 2156767..2156994 + 228 WP_107221087.1 DUF433 domain-containing protein Antitoxin
Tharo_RS10220 2156991..2157332 + 342 WP_107221088.1 DUF5615 family PIN-like protein Toxin
Tharo_RS10230 2157692..2158612 - 921 WP_107221089.1 dTDP-4-dehydrorhamnose reductase -
Tharo_RS10235 2158609..2159679 - 1071 WP_107221090.1 dTDP-glucose 4,6-dehydratase -
Tharo_RS10240 2159793..2160929 - 1137 WP_107221091.1 carotenoid 1,2-hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-79)

Antitoxin

Protein of unknown function DUF433

(9-64)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12699.54 Da        Isoelectric Point: 4.3216

>T101000 WP_107221088.1 NZ_CP028339:2156991-2157332 [Thauera aromatica K172]
MIFWLDAQLPPGLAPWLTETFGVEACSMRYLGLHSAEDAEIFDRARASDDVVLISKDSDFIELITQRGTPPRMLWVTCGN
LTNRRLREVFERLFTDAVALLRAGESIVELGDA

Download         Length: 342 bp

>T101000 NZ_CP028339:2156991-2157332 [Thauera aromatica K172]
ATGATCTTCTGGCTGGATGCCCAACTGCCACCCGGCCTGGCGCCGTGGCTTACCGAAACGTTCGGCGTGGAGGCCTGCTC
GATGCGCTACCTCGGTCTGCACTCAGCCGAGGATGCAGAAATTTTCGATCGGGCGCGAGCCTCGGACGATGTCGTGTTGA
TCAGTAAGGACAGCGACTTCATCGAGCTGATCACACAACGGGGAACGCCCCCGCGGATGCTTTGGGTGACGTGCGGAAAC
CTGACGAACCGGCGCTTGCGGGAGGTTTTCGAGCGCCTGTTTACCGATGCGGTTGCGCTTTTGCGGGCAGGCGAATCCAT
CGTTGAACTGGGAGATGCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8223.59 Da        Isoelectric Point: 4.9295

>AT101000 WP_107221087.1 NZ_CP028339:2156767-2156994 [Thauera aromatica K172]
MNPDLDQRITFNPRQCGGQPCIRGMRIRVADILEMLAQGADQAEILADFPDLELADIMACLHFAAKRAAIARLAA

Download         Length: 228 bp

>AT101000 NZ_CP028339:2156767-2156994 [Thauera aromatica K172]
ATGAACCCCGACCTCGATCAGCGCATCACCTTCAATCCCCGCCAGTGCGGCGGCCAACCTTGCATCCGGGGAATGAGAAT
CCGCGTGGCCGACATCCTCGAGATGCTTGCACAGGGCGCCGATCAGGCTGAAATCCTGGCCGACTTCCCCGACCTGGAGC
TGGCAGACATCATGGCCTGCCTGCATTTCGCCGCGAAACGCGCAGCCATCGCGAGACTGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References