Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2073340..2073974 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Tharo_RS09815 Protein ID WP_107221022.1
Coordinates 2073340..2073741 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Tharo_RS09820 Protein ID WP_107221023.1
Coordinates 2073741..2073974 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS09785 2069668..2071050 - 1383 WP_107221018.1 membrane-bound lytic murein transglycosylase MltF -
Tharo_RS09790 2071117..2071575 - 459 WP_211309683.1 cupin domain-containing protein -
Tharo_RS09795 2071759..2072046 + 288 WP_107221019.1 DUF1778 domain-containing protein -
Tharo_RS09800 2072031..2072537 + 507 WP_211309589.1 GNAT family N-acetyltransferase -
Tharo_RS17735 2072558..2072722 - 165 WP_211309590.1 WecB/TagA/CpsF family glycosyltransferase -
Tharo_RS09810 2072686..2073009 - 324 WP_107221021.1 DUF86 domain-containing protein -
Tharo_RS09815 2073340..2073741 - 402 WP_107221022.1 PIN domain-containing protein Toxin
Tharo_RS09820 2073741..2073974 - 234 WP_107221023.1 antitoxin Antitoxin
Tharo_RS17740 2074204..2074470 + 267 WP_211309591.1 hypothetical protein -
Tharo_RS09830 2074694..2075659 - 966 WP_107221024.1 magnesium/cobalt transporter CorA -
Tharo_RS09835 2075686..2077455 - 1770 WP_107221025.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14478.68 Da        Isoelectric Point: 6.9577

>T100999 WP_107221022.1 NZ_CP028339:c2073741-2073340 [Thauera aromatica K172]
MLRYLLDTNIVICVIKRRPLSALALFNENAGHLAISSITLAELMHGAEKSNAPARSLAAVEDFCCRLEVLPYGPKAAMHY
GNIRAQLESRGQTIGVNDLHIAAHARSEGLTLVSNNLGEFERVEALQLANWAA

Download         Length: 402 bp

>T100999 NZ_CP028339:c2073741-2073340 [Thauera aromatica K172]
ATGCTGCGCTACCTGCTCGACACGAACATCGTAATCTGCGTGATCAAGCGCCGGCCGCTGTCGGCACTTGCGCTGTTCAA
CGAGAACGCCGGGCATCTGGCGATCTCGTCGATTACCCTCGCGGAGCTGATGCACGGCGCCGAGAAAAGCAACGCGCCAG
CGCGTTCGCTTGCCGCTGTCGAGGACTTCTGCTGTCGCCTCGAGGTGCTGCCCTACGGCCCGAAAGCAGCAATGCACTAT
GGCAACATCCGCGCCCAACTGGAATCTCGCGGGCAGACAATCGGCGTCAATGATCTGCACATTGCAGCACACGCACGTAG
CGAGGGTCTGACGCTCGTTTCGAACAACTTGGGCGAGTTCGAGCGAGTGGAAGCATTACAGTTGGCTAACTGGGCAGCCT
GA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8744.84 Da        Isoelectric Point: 7.0120

>AT100999 WP_107221023.1 NZ_CP028339:c2073974-2073741 [Thauera aromatica K172]
MTTSTVFTNNRSQAVRLPADMRLPANVKRVDVRARGLERIIAPVGHTWDSFFINGPQVADDFMETRASQEQQEREAL

Download         Length: 234 bp

>AT100999 NZ_CP028339:c2073974-2073741 [Thauera aromatica K172]
ATGACTACAAGTACCGTCTTCACGAACAATCGCAGCCAGGCCGTGCGACTGCCGGCAGACATGCGCTTGCCCGCGAACGT
CAAGCGCGTGGACGTCCGGGCCCGCGGGTTGGAGCGGATCATCGCGCCGGTAGGCCACACGTGGGATTCGTTCTTCATCA
ACGGGCCGCAGGTTGCCGACGATTTCATGGAAACCCGCGCCAGCCAGGAACAGCAGGAACGCGAGGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References