Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1460140..1460813 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Tharo_RS06965 Protein ID WP_107220579.1
Coordinates 1460140..1460559 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Tharo_RS06970 Protein ID WP_107220580.1
Coordinates 1460556..1460813 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS06940 1455878..1456108 + 231 WP_107222346.1 hypothetical protein -
Tharo_RS06945 1456068..1456643 + 576 WP_107220575.1 sterol desaturase family protein -
Tharo_RS06950 1456775..1457362 + 588 WP_159051667.1 biliverdin-producing heme oxygenase -
Tharo_RS06955 1457359..1459371 + 2013 WP_107220577.1 sensor domain-containing diguanylate cyclase -
Tharo_RS06960 1459431..1460036 - 606 WP_107220578.1 glutathione transferase GstA -
Tharo_RS06965 1460140..1460559 - 420 WP_107220579.1 type II toxin-antitoxin system VapC family toxin Toxin
Tharo_RS06970 1460556..1460813 - 258 WP_107220580.1 plasmid stability protein stbC Antitoxin
Tharo_RS06975 1461072..1461902 + 831 WP_159051668.1 hypothetical protein -
Tharo_RS06980 1462052..1463323 - 1272 WP_107220582.1 bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase -
Tharo_RS06985 1463511..1463786 + 276 WP_107220583.1 DUF1778 domain-containing protein -
Tharo_RS06990 1463787..1464287 + 501 WP_107220584.1 GNAT family N-acetyltransferase -
Tharo_RS06995 1464308..1464703 + 396 WP_107220585.1 DUF423 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15381.85 Da        Isoelectric Point: 8.5039

>T100997 WP_107220579.1 NZ_CP028339:c1460559-1460140 [Thauera aromatica K172]
MIVLDTNVLSELWRLAPDRNVLAWMDAQIVETLFLSAITVAELRFGLAAMPQGKRRTIYQERMEREVLPTFTGRVLPFDL
DASKSYADLMARARAEGLAIGKADGYIAATAAARGMIVATRNTRPFQAAGLAVIDPWDR

Download         Length: 420 bp

>T100997 NZ_CP028339:c1460559-1460140 [Thauera aromatica K172]
ATGATCGTTCTCGATACCAACGTGCTTTCGGAGTTGTGGAGGCTTGCACCCGATCGCAACGTGCTGGCATGGATGGATGC
CCAGATCGTGGAAACCCTTTTCCTGTCCGCCATTACCGTGGCTGAGTTGCGCTTTGGTCTGGCAGCCATGCCGCAAGGCA
AGCGTCGCACGATCTACCAGGAGCGCATGGAACGCGAAGTGCTGCCGACCTTCACCGGGCGCGTTTTGCCTTTTGATCTG
GATGCTTCAAAATCCTATGCCGACCTGATGGCGCGAGCACGCGCAGAGGGTCTGGCCATCGGCAAGGCAGACGGCTACAT
CGCAGCCACCGCAGCCGCACGCGGCATGATCGTCGCCACACGCAACACGAGGCCATTCCAGGCTGCCGGCCTGGCTGTCA
TCGATCCCTGGGACAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9271.56 Da        Isoelectric Point: 5.6999

>AT100997 WP_107220580.1 NZ_CP028339:c1460813-1460556 [Thauera aromatica K172]
MPSITVRNIPDEVHRAIRVRAAMHGCSTEAEVRSILEQAAKPEGRLKLGTLLASIAREAGGLTDEEFALFDNVRDRTPAA
PLSFE

Download         Length: 258 bp

>AT100997 NZ_CP028339:c1460813-1460556 [Thauera aromatica K172]
ATGCCTTCCATCACCGTACGAAACATCCCTGACGAGGTGCACCGCGCCATCCGTGTTCGCGCCGCCATGCACGGGTGCAG
CACCGAGGCTGAAGTTCGCAGCATCCTTGAACAAGCAGCGAAGCCCGAAGGGCGCCTGAAACTCGGGACACTGCTGGCTT
CCATCGCCCGCGAGGCAGGCGGCTTGACCGACGAAGAATTCGCCCTCTTCGACAACGTGCGCGACAGAACCCCGGCTGCG
CCGCTGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References