Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1143334..1143902 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Tharo_RS05505 Protein ID WP_107220333.1
Coordinates 1143334..1143705 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Tharo_RS05510 Protein ID WP_107220334.1
Coordinates 1143702..1143902 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS05475 1139038..1139613 + 576 WP_107222323.1 phospholipase D family protein -
Tharo_RS05480 1139757..1140200 - 444 WP_107220330.1 6-carboxytetrahydropterin synthase QueD -
Tharo_RS05485 1140288..1141166 + 879 WP_107220331.1 radical SAM protein -
Tharo_RS05490 1141182..1141475 - 294 WP_075149583.1 helix-turn-helix domain-containing protein -
Tharo_RS05495 1141734..1142960 + 1227 WP_107220332.1 aspartate kinase -
Tharo_RS05505 1143334..1143705 - 372 WP_107220333.1 type II toxin-antitoxin system VapC family toxin Toxin
Tharo_RS05510 1143702..1143902 - 201 WP_107220334.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
Tharo_RS05515 1144161..1144409 + 249 WP_107220335.1 hypothetical protein -
Tharo_RS05520 1144492..1145853 + 1362 WP_107222324.1 alkaline phosphatase D family protein -
Tharo_RS05525 1145965..1146204 - 240 WP_107220336.1 TM0996/MTH895 family glutaredoxin-like protein -
Tharo_RS05530 1146207..1147670 - 1464 WP_107220337.1 permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-109)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13216.32 Da        Isoelectric Point: 6.6037

>T100996 WP_107220333.1 NZ_CP028339:c1143705-1143334 [Thauera aromatica K172]
MILVDTSIWIDHLRGSDQHLSALLAEGRVVMHPHVLGEVALGNLKNRTAVLGAMSDLPQAVAATDDEVLHFIEAQGLFGL
GIGYMDAHLLAAVMLAPGTRLWTRDRRLSTASARLGLAYALAH

Download         Length: 372 bp

>T100996 NZ_CP028339:c1143705-1143334 [Thauera aromatica K172]
ATGATCCTCGTCGATACGTCGATCTGGATCGACCACCTGCGTGGCTCGGATCAACACCTCTCTGCGCTTCTGGCAGAGGG
GCGGGTGGTGATGCATCCGCATGTGCTGGGCGAAGTCGCACTCGGCAACCTGAAAAACCGTACCGCCGTGCTGGGTGCGA
TGAGCGATCTCCCGCAGGCGGTGGCGGCAACGGACGACGAGGTGCTGCACTTCATCGAAGCGCAGGGGCTTTTCGGGCTG
GGTATCGGTTACATGGATGCGCATTTGCTCGCCGCCGTGATGCTGGCGCCCGGAACAAGGCTGTGGACGCGCGACCGGCG
CCTGAGCACCGCAAGTGCTCGCCTCGGTCTGGCCTATGCGCTCGCCCACTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7207.32 Da        Isoelectric Point: 8.8963

>AT100996 WP_107220334.1 NZ_CP028339:c1143902-1143702 [Thauera aromatica K172]
MRTTLALDDELLAKAQALTGLTEKSTLVKEALRALIQRESARRLALLGGSEPQLNDIPRRQPEPAA

Download         Length: 201 bp

>AT100996 NZ_CP028339:c1143902-1143702 [Thauera aromatica K172]
ATGCGCACCACCCTCGCACTCGACGACGAGTTGCTGGCCAAGGCTCAGGCACTGACCGGACTGACCGAGAAATCCACCTT
GGTAAAGGAAGCCCTGCGCGCGCTGATCCAGCGCGAAAGCGCCCGGCGCCTCGCCCTGTTGGGCGGCTCGGAGCCTCAAC
TGAACGACATCCCGCGGCGGCAGCCGGAACCTGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References