Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1104046..1104565 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Tharo_RS05315 Protein ID WP_107220300.1
Coordinates 1104284..1104565 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag Tharo_RS05310 Protein ID WP_107222321.1
Coordinates 1104046..1104294 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS05285 1099203..1099493 + 291 WP_004311482.1 co-chaperone GroES -
Tharo_RS05290 1099546..1101195 + 1650 WP_107220298.1 chaperonin GroEL -
Tharo_RS05295 1101363..1102049 + 687 WP_075147443.1 response regulator transcription factor -
Tharo_RS05300 1102024..1103496 + 1473 WP_107220299.1 sensor histidine kinase N-terminal domain-containing protein -
Tharo_RS05310 1104046..1104294 + 249 WP_107222321.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Tharo_RS05315 1104284..1104565 + 282 WP_107220300.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Tharo_RS05320 1104759..1105970 + 1212 WP_107220301.1 Bcr/CflA family efflux MFS transporter -
Tharo_RS05325 1106228..1107481 + 1254 WP_107220302.1 glutamyl-tRNA reductase -
Tharo_RS05330 1107540..1108625 + 1086 WP_107220303.1 peptide chain release factor 1 -
Tharo_RS05335 1108622..1109491 + 870 WP_107220304.1 peptide chain release factor N(5)-glutamine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10663.44 Da        Isoelectric Point: 10.2587

>T100995 WP_107220300.1 NZ_CP028339:1104284-1104565 [Thauera aromatica K172]
MSYELGFVDEVLAEWRKLDGSVREQFKKKLAERLDTPRVPAAKLSGHPDRYKIKLCSVGYRLVYEVRDQQLIVVVIAVGK
RDRNAVYKAAGVR

Download         Length: 282 bp

>T100995 NZ_CP028339:1104284-1104565 [Thauera aromatica K172]
ATGAGCTATGAGCTCGGGTTCGTCGATGAGGTCCTGGCTGAGTGGCGAAAACTCGATGGCAGCGTCCGAGAGCAGTTCAA
GAAGAAGCTTGCCGAGCGCCTGGACACGCCGCGTGTGCCGGCAGCAAAACTCAGTGGGCATCCGGACCGCTACAAAATCA
AGCTTTGCAGTGTTGGCTACCGCCTGGTCTATGAGGTGCGGGACCAGCAACTGATTGTGGTCGTCATTGCGGTGGGGAAG
CGGGACCGCAATGCGGTGTACAAGGCGGCGGGCGTACGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8857.31 Da        Isoelectric Point: 4.7023

>AT100995 WP_107222321.1 NZ_CP028339:1104046-1104294 [Thauera aromatica K172]
MAHLILAETTASVSELKKNPMGTVAAGEGMPVAILNRNAPAFYCVPAKAYEALMDRLEDLELNALADVRAGQRVTRVMLD
EL

Download         Length: 249 bp

>AT100995 NZ_CP028339:1104046-1104294 [Thauera aromatica K172]
ATGGCGCACCTGATTCTGGCGGAAACCACCGCGAGCGTTTCCGAGCTGAAGAAGAACCCCATGGGTACGGTTGCAGCCGG
CGAGGGGATGCCGGTGGCCATTCTGAATCGCAACGCGCCAGCCTTCTATTGCGTTCCCGCAAAGGCGTACGAAGCGCTGA
TGGACCGCCTCGAGGATTTGGAGCTGAATGCCCTTGCCGACGTCCGTGCCGGCCAGCGCGTCACCAGGGTCATGCTCGAT
GAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References