Detailed information of TA system TA100995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1104046..1104565
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Tharo_RS05315
• Protein ID: WP_107220300.1
• Coordinates: 1104284..1104565 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Tharo_RS05310
• Protein ID: WP_107222321.1
• Coordinates: 1104046..1104294 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS05285	1099203..1099493	+	291	WP_004311482.1	co-chaperone GroES	-
Tharo_RS05290	1099546..1101195	+	1650	WP_107220298.1	chaperonin GroEL	-
Tharo_RS05295	1101363..1102049	+	687	WP_075147443.1	response regulator transcription factor	-
Tharo_RS05300	1102024..1103496	+	1473	WP_107220299.1	sensor histidine kinase N-terminal domain-containing protein	-
Tharo_RS05310	1104046..1104294	+	249	WP_107222321.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Tharo_RS05315	1104284..1104565	+	282	WP_107220300.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Tharo_RS05320	1104759..1105970	+	1212	WP_107220301.1	Bcr/CflA family efflux MFS transporter	-
Tharo_RS05325	1106228..1107481	+	1254	WP_107220302.1	glutamyl-tRNA reductase	-
Tharo_RS05330	1107540..1108625	+	1086	WP_107220303.1	peptide chain release factor 1	-
Tharo_RS05335	1108622..1109491	+	870	WP_107220304.1	peptide chain release factor N(5)-glutamine methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10663.44 Da
• Isoelectric Point: 10.2587

>T100995 WP_107220300.1 NZ_CP028339:1104284-1104565 [Thauera aromatica K172]
MSYELGFVDEVLAEWRKLDGSVREQFKKKLAERLDTPRVPAAKLSGHPDRYKIKLCSVGYRLVYEVRDQQLIVVVIAVGK
RDRNAVYKAAGVR

Nucleotide

• Length: 282 bp

>T100995 NZ_CP028339:1104284-1104565 [Thauera aromatica K172]
ATGAGCTATGAGCTCGGGTTCGTCGATGAGGTCCTGGCTGAGTGGCGAAAACTCGATGGCAGCGTCCGAGAGCAGTTCAA
GAAGAAGCTTGCCGAGCGCCTGGACACGCCGCGTGTGCCGGCAGCAAAACTCAGTGGGCATCCGGACCGCTACAAAATCA
AGCTTTGCAGTGTTGGCTACCGCCTGGTCTATGAGGTGCGGGACCAGCAACTGATTGTGGTCGTCATTGCGGTGGGGAAG
CGGGACCGCAATGCGGTGTACAAGGCGGCGGGCGTACGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8857.31 Da
• Isoelectric Point: 4.7023

>AT100995 WP_107222321.1 NZ_CP028339:1104046-1104294 [Thauera aromatica K172]
MAHLILAETTASVSELKKNPMGTVAAGEGMPVAILNRNAPAFYCVPAKAYEALMDRLEDLELNALADVRAGQRVTRVMLD
EL

Nucleotide

• Length: 249 bp

>AT100995 NZ_CP028339:1104046-1104294 [Thauera aromatica K172]
ATGGCGCACCTGATTCTGGCGGAAACCACCGCGAGCGTTTCCGAGCTGAAGAAGAACCCCATGGGTACGGTTGCAGCCGG
CGAGGGGATGCCGGTGGCCATTCTGAATCGCAACGCGCCAGCCTTCTATTGCGTTCCCGCAAAGGCGTACGAAGCGCTGA
TGGACCGCCTCGAGGATTTGGAGCTGAATGCCCTTGCCGACGTCCGTGCCGGCCAGCGCGTCACCAGGGTCATGCTCGAT
GAGCTATGA