Detailed information of TA system TA100994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 993848..994373
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Tharo_RS04815
• Protein ID: WP_107220221.1
• Coordinates: 994095..994373 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: Tharo_RS04810
• Protein ID: WP_107220220.1
• Coordinates: 993848..994105 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS04760	989761..990288	+	528	WP_107220214.1	tetratricopeptide repeat protein	-
Tharo_RS04765	990603..990926	-	324	Protein_939	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
Tharo_RS04770	990913..991164	-	252	WP_107220215.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
Tharo_RS04775	991373..991696	+	324	WP_107220216.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Tharo_RS04780	991689..991979	+	291	WP_107220217.1	transcriptional regulator	-
Tharo_RS04785	992077..992457	+	381	WP_107220218.1	clan AA aspartic protease	-
Tharo_RS04790	992464..992697	+	234	Protein_944	transposase	-
Tharo_RS04800	993220..993432	+	213	WP_107220219.1	hypothetical protein	-
Tharo_RS04805	993429..993700	+	272	Protein_946	type II toxin-antitoxin system RelE/ParE family toxin	-
Tharo_RS04810	993848..994105	+	258	WP_107220220.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Tharo_RS04815	994095..994373	+	279	WP_107220221.1	Txe/YoeB family addiction module toxin	Toxin
Tharo_RS17725	994490..994831	-	342	WP_211309658.1	hypothetical protein	-
Tharo_RS04825	994949..995551	+	603	WP_107220222.1	hypothetical protein	-
Tharo_RS04830	995548..997296	+	1749	WP_107220223.1	type I secretion system permease/ATPase	-
Tharo_RS04835	997335..999083	+	1749	WP_107222311.1	type I secretion system permease/ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (12-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10937.68 Da
• Isoelectric Point: 8.1281

>T100994 WP_107220221.1 NZ_CP028339:994095-994373 [Thauera aromatica K172]
MPIEDKLLKLTWTLAACEDYEYWQGRDRKTLKRINALIKDCLRHPFEGIGKPEPLKENLSGFWSRRIDDTHRLVYCLDAQ
ALVVIACRYHYQ

Nucleotide

• Length: 279 bp

>T100994 NZ_CP028339:994095-994373 [Thauera aromatica K172]
ATGCCGATTGAAGACAAGCTGCTCAAACTCACCTGGACCCTGGCCGCCTGTGAGGATTACGAATACTGGCAAGGCCGGGA
CCGCAAGACCCTCAAGCGCATCAATGCCCTGATCAAGGACTGCCTGCGCCACCCCTTCGAGGGCATCGGCAAACCCGAGC
CCTTGAAAGAGAACCTCTCGGGCTTTTGGTCGCGCCGTATCGACGACACCCACCGGCTGGTCTACTGCCTGGATGCGCAG
GCCTTGGTGGTGATTGCCTGTCGTTACCACTACCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9527.73 Da
• Isoelectric Point: 4.7027

>AT100994 WP_107220220.1 NZ_CP028339:993848-994105 [Thauera aromatica K172]
MRVVNFSEARNSLKNVIDQVIDDADYTVIARRDAPDAVVMSLDTFNGLMETVHLLKSPANAAHLVRSIEQYRQGQVKQQD
LVDAD

Nucleotide

• Length: 258 bp

>AT100994 NZ_CP028339:993848-994105 [Thauera aromatica K172]
ATGCGTGTGGTGAATTTCTCTGAGGCACGAAATAGCCTCAAAAACGTGATCGACCAGGTCATCGACGATGCCGACTACAC
GGTCATTGCGCGCCGGGATGCCCCCGATGCCGTGGTGATGTCGCTGGACACCTTCAATGGCCTGATGGAGACCGTCCATT
TGCTGAAGTCGCCCGCCAATGCGGCACATCTGGTCCGCTCCATCGAGCAGTACCGCCAGGGACAGGTGAAGCAGCAGGAC
CTGGTCGATGCCGATTGA