Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 993848..994373 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Tharo_RS04815 Protein ID WP_107220221.1
Coordinates 994095..994373 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag Tharo_RS04810 Protein ID WP_107220220.1
Coordinates 993848..994105 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS04760 989761..990288 + 528 WP_107220214.1 tetratricopeptide repeat protein -
Tharo_RS04765 990603..990926 - 324 Protein_939 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
Tharo_RS04770 990913..991164 - 252 WP_107220215.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
Tharo_RS04775 991373..991696 + 324 WP_107220216.1 type II toxin-antitoxin system RelE/ParE family toxin -
Tharo_RS04780 991689..991979 + 291 WP_107220217.1 transcriptional regulator -
Tharo_RS04785 992077..992457 + 381 WP_107220218.1 clan AA aspartic protease -
Tharo_RS04790 992464..992697 + 234 Protein_944 transposase -
Tharo_RS04800 993220..993432 + 213 WP_107220219.1 hypothetical protein -
Tharo_RS04805 993429..993700 + 272 Protein_946 type II toxin-antitoxin system RelE/ParE family toxin -
Tharo_RS04810 993848..994105 + 258 WP_107220220.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Tharo_RS04815 994095..994373 + 279 WP_107220221.1 Txe/YoeB family addiction module toxin Toxin
Tharo_RS17725 994490..994831 - 342 WP_211309658.1 hypothetical protein -
Tharo_RS04825 994949..995551 + 603 WP_107220222.1 hypothetical protein -
Tharo_RS04830 995548..997296 + 1749 WP_107220223.1 type I secretion system permease/ATPase -
Tharo_RS04835 997335..999083 + 1749 WP_107222311.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(12-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10937.68 Da        Isoelectric Point: 8.1281

>T100994 WP_107220221.1 NZ_CP028339:994095-994373 [Thauera aromatica K172]
MPIEDKLLKLTWTLAACEDYEYWQGRDRKTLKRINALIKDCLRHPFEGIGKPEPLKENLSGFWSRRIDDTHRLVYCLDAQ
ALVVIACRYHYQ

Download         Length: 279 bp

>T100994 NZ_CP028339:994095-994373 [Thauera aromatica K172]
ATGCCGATTGAAGACAAGCTGCTCAAACTCACCTGGACCCTGGCCGCCTGTGAGGATTACGAATACTGGCAAGGCCGGGA
CCGCAAGACCCTCAAGCGCATCAATGCCCTGATCAAGGACTGCCTGCGCCACCCCTTCGAGGGCATCGGCAAACCCGAGC
CCTTGAAAGAGAACCTCTCGGGCTTTTGGTCGCGCCGTATCGACGACACCCACCGGCTGGTCTACTGCCTGGATGCGCAG
GCCTTGGTGGTGATTGCCTGTCGTTACCACTACCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9527.73 Da        Isoelectric Point: 4.7027

>AT100994 WP_107220220.1 NZ_CP028339:993848-994105 [Thauera aromatica K172]
MRVVNFSEARNSLKNVIDQVIDDADYTVIARRDAPDAVVMSLDTFNGLMETVHLLKSPANAAHLVRSIEQYRQGQVKQQD
LVDAD

Download         Length: 258 bp

>AT100994 NZ_CP028339:993848-994105 [Thauera aromatica K172]
ATGCGTGTGGTGAATTTCTCTGAGGCACGAAATAGCCTCAAAAACGTGATCGACCAGGTCATCGACGATGCCGACTACAC
GGTCATTGCGCGCCGGGATGCCCCCGATGCCGTGGTGATGTCGCTGGACACCTTCAATGGCCTGATGGAGACCGTCCATT
TGCTGAAGTCGCCCGCCAATGCGGCACATCTGGTCCGCTCCATCGAGCAGTACCGCCAGGGACAGGTGAAGCAGCAGGAC
CTGGTCGATGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References