Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 832792..833450 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Tharo_RS04060 Protein ID WP_107220090.1
Coordinates 832792..833205 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Tharo_RS04065 Protein ID WP_107220091.1
Coordinates 833202..833450 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS04025 827997..830057 + 2061 WP_107220084.1 ATP-dependent DNA helicase RecG -
Tharo_RS04030 830109..830534 - 426 WP_107220085.1 putative toxin-antitoxin system toxin component, PIN family -
Tharo_RS04035 830531..830755 - 225 WP_107220086.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
Tharo_RS04040 830947..831819 + 873 WP_107220087.1 4-hydroxybenzoate octaprenyltransferase -
Tharo_RS04050 832048..832278 + 231 WP_107220088.1 type II toxin-antitoxin system PrlF family antitoxin -
Tharo_RS04055 832268..832603 + 336 WP_107220089.1 type II toxin-antitoxin system PemK/MazF family toxin -
Tharo_RS04060 832792..833205 - 414 WP_107220090.1 type II toxin-antitoxin system VapC family toxin Toxin
Tharo_RS04065 833202..833450 - 249 WP_107220091.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Tharo_RS04070 833731..833976 + 246 WP_107220092.1 hypothetical protein -
Tharo_RS04075 834129..834956 + 828 WP_107220093.1 orotidine-5'-phosphate decarboxylase -
Tharo_RS04080 835036..836532 + 1497 WP_107220094.1 4-hydroxy-3-polyprenylbenzoate decarboxylase -
Tharo_RS04085 836660..837079 + 420 WP_107220095.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-60)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15206.49 Da        Isoelectric Point: 6.4705

>T100992 WP_107220090.1 NZ_CP028339:c833205-832792 [Thauera aromatica K172]
MSYLIDTNVLSELRRKSPDPGVVDWFSQRPPTTLHLSVLTLGEIRKGIEGVDDEIRRQSLTDWLKTDLPAFFTGRILSID
GAVADRWGRLIAAAGRPLPAIDSLLAATALEHDLVLVTRNVKGFFGLPVQIFNPWSN

Download         Length: 414 bp

>T100992 NZ_CP028339:c833205-832792 [Thauera aromatica K172]
TTGAGCTACTTGATCGACACCAACGTCCTGTCCGAACTGCGGCGCAAGTCGCCCGACCCCGGCGTGGTCGACTGGTTCTC
GCAACGACCACCGACCACACTGCACCTATCGGTGCTGACGCTTGGGGAAATTCGCAAGGGCATCGAGGGAGTGGATGACG
AGATACGCCGACAGTCGTTGACCGACTGGCTGAAAACTGATCTACCGGCTTTCTTTACCGGGCGCATTCTCAGTATCGAT
GGGGCAGTCGCCGACCGCTGGGGCCGGTTGATCGCTGCAGCGGGGCGGCCACTACCGGCCATCGACAGTCTGCTCGCGGC
CACCGCGCTGGAACACGACTTGGTATTGGTCACCCGCAACGTCAAAGGCTTCTTCGGCCTGCCCGTCCAGATATTCAACC
CCTGGTCGAATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9458.69 Da        Isoelectric Point: 7.2031

>AT100992 WP_107220091.1 NZ_CP028339:c833450-833202 [Thauera aromatica K172]
MHTWQMQEAKARMSELVKRAQTQPQDITLHGKSVAVVISRETFDRLSQAQDSLVDFMRRSPLYGADDITFGRDQSLTREV
TF

Download         Length: 249 bp

>AT100992 NZ_CP028339:c833450-833202 [Thauera aromatica K172]
ATGCACACATGGCAAATGCAGGAAGCCAAGGCCCGGATGTCGGAGTTGGTCAAGCGTGCCCAGACGCAACCCCAAGACAT
CACCCTGCACGGCAAGTCGGTGGCCGTCGTGATCTCGCGTGAGACCTTTGACCGCCTGTCGCAGGCGCAGGATTCGCTGG
TGGACTTCATGCGCCGCTCACCCCTGTATGGCGCCGATGACATCACCTTCGGGCGCGACCAGAGCTTGACGCGCGAGGTC
ACGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References