Detailed information of TA system TA100992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 832792..833450
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Tharo_RS04060
• Protein ID: WP_107220090.1
• Coordinates: 832792..833205 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: Tharo_RS04065
• Protein ID: WP_107220091.1
• Coordinates: 833202..833450 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS04025	827997..830057	+	2061	WP_107220084.1	ATP-dependent DNA helicase RecG	-
Tharo_RS04030	830109..830534	-	426	WP_107220085.1	putative toxin-antitoxin system toxin component, PIN family	-
Tharo_RS04035	830531..830755	-	225	WP_107220086.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
Tharo_RS04040	830947..831819	+	873	WP_107220087.1	4-hydroxybenzoate octaprenyltransferase	-
Tharo_RS04050	832048..832278	+	231	WP_107220088.1	type II toxin-antitoxin system PrlF family antitoxin	-
Tharo_RS04055	832268..832603	+	336	WP_107220089.1	type II toxin-antitoxin system PemK/MazF family toxin	-
Tharo_RS04060	832792..833205	-	414	WP_107220090.1	type II toxin-antitoxin system VapC family toxin	Toxin
Tharo_RS04065	833202..833450	-	249	WP_107220091.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Tharo_RS04070	833731..833976	+	246	WP_107220092.1	hypothetical protein	-
Tharo_RS04075	834129..834956	+	828	WP_107220093.1	orotidine-5'-phosphate decarboxylase	-
Tharo_RS04080	835036..836532	+	1497	WP_107220094.1	4-hydroxy-3-polyprenylbenzoate decarboxylase	-
Tharo_RS04085	836660..837079	+	420	WP_107220095.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-60)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15206.49 Da
• Isoelectric Point: 6.4705

>T100992 WP_107220090.1 NZ_CP028339:c833205-832792 [Thauera aromatica K172]
MSYLIDTNVLSELRRKSPDPGVVDWFSQRPPTTLHLSVLTLGEIRKGIEGVDDEIRRQSLTDWLKTDLPAFFTGRILSID
GAVADRWGRLIAAAGRPLPAIDSLLAATALEHDLVLVTRNVKGFFGLPVQIFNPWSN

Nucleotide

• Length: 414 bp

>T100992 NZ_CP028339:c833205-832792 [Thauera aromatica K172]
TTGAGCTACTTGATCGACACCAACGTCCTGTCCGAACTGCGGCGCAAGTCGCCCGACCCCGGCGTGGTCGACTGGTTCTC
GCAACGACCACCGACCACACTGCACCTATCGGTGCTGACGCTTGGGGAAATTCGCAAGGGCATCGAGGGAGTGGATGACG
AGATACGCCGACAGTCGTTGACCGACTGGCTGAAAACTGATCTACCGGCTTTCTTTACCGGGCGCATTCTCAGTATCGAT
GGGGCAGTCGCCGACCGCTGGGGCCGGTTGATCGCTGCAGCGGGGCGGCCACTACCGGCCATCGACAGTCTGCTCGCGGC
CACCGCGCTGGAACACGACTTGGTATTGGTCACCCGCAACGTCAAAGGCTTCTTCGGCCTGCCCGTCCAGATATTCAACC
CCTGGTCGAATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9458.69 Da
• Isoelectric Point: 7.2031

>AT100992 WP_107220091.1 NZ_CP028339:c833450-833202 [Thauera aromatica K172]
MHTWQMQEAKARMSELVKRAQTQPQDITLHGKSVAVVISRETFDRLSQAQDSLVDFMRRSPLYGADDITFGRDQSLTREV
TF

Nucleotide

• Length: 249 bp

>AT100992 NZ_CP028339:c833450-833202 [Thauera aromatica K172]
ATGCACACATGGCAAATGCAGGAAGCCAAGGCCCGGATGTCGGAGTTGGTCAAGCGTGCCCAGACGCAACCCCAAGACAT
CACCCTGCACGGCAAGTCGGTGGCCGTCGTGATCTCGCGTGAGACCTTTGACCGCCTGTCGCAGGCGCAGGATTCGCTGG
TGGACTTCATGCGCCGCTCACCCCTGTATGGCGCCGATGACATCACCTTCGGGCGCGACCAGAGCTTGACGCGCGAGGTC
ACGTTTTGA