Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PrlF(antitoxin)
Location 832048..832603 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Tharo_RS04055 Protein ID WP_107220089.1
Coordinates 832268..832603 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Tharo_RS04050 Protein ID WP_107220088.1
Coordinates 832048..832278 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS04020 827589..827969 + 381 WP_107220083.1 RidA family protein -
Tharo_RS04025 827997..830057 + 2061 WP_107220084.1 ATP-dependent DNA helicase RecG -
Tharo_RS04030 830109..830534 - 426 WP_107220085.1 putative toxin-antitoxin system toxin component, PIN family -
Tharo_RS04035 830531..830755 - 225 WP_107220086.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
Tharo_RS04040 830947..831819 + 873 WP_107220087.1 4-hydroxybenzoate octaprenyltransferase -
Tharo_RS04050 832048..832278 + 231 WP_107220088.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
Tharo_RS04055 832268..832603 + 336 WP_107220089.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Tharo_RS04060 832792..833205 - 414 WP_107220090.1 type II toxin-antitoxin system VapC family toxin -
Tharo_RS04065 833202..833450 - 249 WP_107220091.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
Tharo_RS04070 833731..833976 + 246 WP_107220092.1 hypothetical protein -
Tharo_RS04075 834129..834956 + 828 WP_107220093.1 orotidine-5'-phosphate decarboxylase -
Tharo_RS04080 835036..836532 + 1497 WP_107220094.1 4-hydroxy-3-polyprenylbenzoate decarboxylase -
Tharo_RS04085 836660..837079 + 420 WP_107220095.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin

PrlF antitoxin

(6-47)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12113.89 Da        Isoelectric Point: 7.1661

>T100991 WP_107220089.1 NZ_CP028339:832268-832603 [Thauera aromatica K172]
VSFDRFTVVRVPFPFTDRNATKNRPALVLSAADSFNTPTGHSVMAMITSADNVPWPLDCQIADLKSAGLPAPSVVRFKLF
TLDHRLVRGELGVLAIGDTQSVADRLEQLFS

Download         Length: 336 bp

>T100991 NZ_CP028339:832268-832603 [Thauera aromatica K172]
GTGAGCTTTGATCGCTTCACCGTGGTGCGCGTACCGTTTCCCTTCACCGACCGTAATGCCACCAAGAACCGCCCGGCGCT
GGTGCTTTCCGCTGCTGACAGTTTCAATACGCCCACCGGCCATTCCGTGATGGCGATGATCACCTCAGCCGATAACGTCC
CATGGCCGCTCGACTGCCAGATCGCCGACTTGAAGAGTGCCGGCCTGCCGGCACCATCCGTTGTGCGCTTCAAATTGTTC
ACGCTGGATCATCGACTGGTGCGAGGCGAGTTGGGAGTTCTCGCCATCGGTGACACTCAGTCAGTTGCTGACAGACTCGA
ACAACTATTCTCGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8264.36 Da        Isoelectric Point: 4.7361

>AT100991 WP_107220088.1 NZ_CP028339:832048-832278 [Thauera aromatica K172]
MLAVGKITAKGQTTIPRDVRAALHVAPGDLIAWEVSADGTATVRRVQPLDIEYLRAVEGTLSEWSGKADEEAYREL

Download         Length: 231 bp

>AT100991 NZ_CP028339:832048-832278 [Thauera aromatica K172]
ATGCTTGCCGTTGGCAAAATTACCGCCAAAGGCCAGACCACCATTCCGCGGGACGTGCGTGCCGCCCTGCATGTCGCGCC
AGGCGACCTTATCGCCTGGGAGGTCAGCGCGGACGGCACGGCGACCGTACGCCGCGTGCAACCGCTCGATATCGAATACC
TGCGCGCGGTCGAAGGCACGCTGTCGGAATGGTCGGGAAAAGCCGATGAGGAAGCCTACCGTGAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References