Detailed information of TA system TA100990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 395402..396009
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Tharo_RS01920
• Protein ID: WP_107219760.1
• Coordinates: 395839..396009 (-)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: Tharo_RS01915
• Protein ID: WP_107219759.1
• Coordinates: 395402..395827 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS01875	390627..391316	+	690	WP_159051646.1	DUF4351 domain-containing protein	-
Tharo_RS01880	391380..391691	-	312	WP_107219753.1	helix-turn-helix domain-containing protein	-
Tharo_RS01885	391684..392010	-	327	WP_107219754.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Tharo_RS01890	392175..392513	-	339	Protein_370	type II toxin-antitoxin system HicB family antitoxin	-
Tharo_RS17705	392820..393044	+	225	Protein_371	Rpn family recombination-promoting nuclease/putative transposase	-
Tharo_RS01900	393371..394396	+	1026	WP_107219756.1	Rpn family recombination-promoting nuclease/putative transposase	-
Tharo_RS17630	394419..394646	-	228	WP_170109998.1	hypothetical protein	-
Tharo_RS01905	394643..394990	-	348	WP_107219757.1	DNA-binding protein	-
Tharo_RS01910	394971..395267	-	297	WP_211309648.1	hypothetical protein	-
Tharo_RS01915	395402..395827	-	426	WP_107219759.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Tharo_RS01920	395839..396009	-	171	WP_107219760.1	type II toxin-antitoxin system HicA family toxin	Toxin
Tharo_RS01925	396445..396636	+	192	WP_107219761.1	hypothetical protein	-
Tharo_RS01930	396582..397640	+	1059	WP_107219762.1	Rpn family recombination-promoting nuclease/putative transposase	-
Tharo_RS01935	397749..397997	+	249	WP_159051648.1	ribbon-helix-helix protein, CopG family	-
Tharo_RS01940	397994..398413	+	420	WP_107219764.1	PIN domain-containing protein	-
Tharo_RS01945	398757..400442	+	1686	WP_107219765.1	PilZ domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	387433..397640	10207

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-51)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6322.31 Da
• Isoelectric Point: 11.0566

>T100990 WP_107219760.1 NZ_CP028339:c396009-395839 [Thauera aromatica K172]
MNGTDLIKQQERGGWELANVRGSHHVFRHPDKPGHISVPHPRKDLAHKLLKLAGLK

Nucleotide

• Length: 171 bp

>T100990 NZ_CP028339:c396009-395839 [Thauera aromatica K172]
ATGAACGGCACAGACCTGATCAAGCAACAGGAACGCGGCGGCTGGGAGCTGGCCAACGTGCGCGGCTCTCACCACGTGTT
CCGCCACCCGGACAAGCCCGGCCACATCAGCGTGCCGCACCCGCGCAAGGACCTGGCGCACAAGCTGTTGAAGCTGGCCG
GGCTCAAGTAA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 14960.86 Da
• Isoelectric Point: 4.4242

>AT100990 WP_107219759.1 NZ_CP028339:c395827-395402 [Thauera aromatica K172]
MKYPIAIEPGDGTHAWGVVVPDLPGCFSAADSGIDEATDNAKEAIAAWIEAVMDDGGDIPAPTSIAAHRANPEFDGWIWA
VAEVDPAILDDKAERVNITLPRRVLARLDARARAAGETRSGYIAKLAIEARPIFTPGSVSR

Nucleotide

• Length: 426 bp

>AT100990 NZ_CP028339:c395827-395402 [Thauera aromatica K172]
ATGAAATACCCGATTGCAATCGAGCCGGGCGACGGGACGCACGCCTGGGGCGTGGTGGTGCCCGACCTGCCGGGCTGCTT
TTCGGCGGCCGACAGCGGCATCGACGAAGCCACCGACAACGCCAAGGAAGCCATTGCGGCGTGGATCGAGGCGGTGATGG
ACGACGGCGGCGACATTCCAGCACCGACCTCCATCGCGGCGCACCGCGCCAATCCCGAATTCGATGGATGGATCTGGGCC
GTGGCCGAAGTCGACCCCGCCATCCTCGACGACAAGGCCGAGCGGGTGAACATCACCCTGCCACGCCGCGTGCTGGCCCG
GCTCGATGCGCGCGCCCGTGCCGCGGGTGAAACCCGCTCGGGCTACATCGCCAAGCTCGCCATCGAGGCCCGGCCGATTT
TCACGCCCGGCTCCGTTTCGCGGTGA