Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 378624..379262 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Tharo_RS01795 Protein ID WP_107219738.1
Coordinates 378861..379262 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Tharo_RS01790 Protein ID WP_107219737.1
Coordinates 378624..378854 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS01775 375196..375519 + 324 WP_107219734.1 flagellar hook-basal body complex protein FliE -
Tharo_RS01780 375671..376033 - 363 WP_107219735.1 flagellar protein FlaG -
Tharo_RS01785 376092..378086 - 1995 WP_107219736.1 methyl-accepting chemotaxis protein -
Tharo_RS01790 378624..378854 + 231 WP_107219737.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Tharo_RS01795 378861..379262 + 402 WP_107219738.1 PIN domain-containing protein Toxin
Tharo_RS01800 379446..379580 - 135 WP_107219739.1 hypothetical protein -
Tharo_RS01805 379708..380121 - 414 WP_107219740.1 helix-turn-helix domain-containing protein -
Tharo_RS01810 380118..380405 - 288 WP_107219741.1 type II toxin-antitoxin system HigB family toxin -
Tharo_RS01815 380789..381478 + 690 WP_107219742.1 DUF4325 domain-containing protein -
Tharo_RS01820 381493..381729 - 237 WP_107219743.1 DUF1640 domain-containing protein -
Tharo_RS01825 381867..382178 - 312 WP_107219744.1 helix-turn-helix domain-containing protein -
Tharo_RS01830 382180..382476 - 297 WP_107219745.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-40)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14219.42 Da        Isoelectric Point: 7.3207

>T100988 WP_107219738.1 NZ_CP028339:378861-379262 [Thauera aromatica K172]
MTHLLDTNIFIAALKAHPAVRARLESLPASAVVLSPIVLGELQTGVEKSEQVERNRARLEQVVAGLAVPRVDAATSAHYA
RIRAALERQGTPIGGNDLWIAAQALALGAVLVTDNVKEFSRVPGLVVENWLAQ

Download         Length: 402 bp

>T100988 NZ_CP028339:378861-379262 [Thauera aromatica K172]
ATGACGCACCTGCTCGATACCAATATCTTCATCGCTGCGCTGAAGGCCCACCCGGCGGTTCGCGCGCGGCTCGAGTCCTT
GCCGGCCTCTGCAGTCGTTCTTTCGCCCATCGTCCTGGGCGAACTCCAGACCGGTGTGGAGAAGAGCGAACAGGTCGAGC
GTAACCGTGCACGGCTGGAGCAGGTGGTTGCGGGGCTTGCGGTGCCGCGGGTGGATGCCGCGACGAGCGCCCACTATGCA
CGGATCCGTGCCGCGCTCGAGCGGCAAGGCACGCCGATCGGTGGTAATGATCTCTGGATTGCGGCGCAGGCGCTTGCCCT
TGGTGCCGTGCTGGTCACCGATAACGTGAAGGAGTTCAGCCGCGTTCCGGGCCTGGTGGTGGAGAACTGGCTGGCTCAGT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8007.05 Da        Isoelectric Point: 4.4645

>AT100988 WP_107219737.1 NZ_CP028339:378624-378854 [Thauera aromatica K172]
MRTVAVVEAKSQFSALLAAVEGGEEVAITRRGRVVARLVPDTTRSAADVFRPCWQEGGLDLAAPADTPAEPVAGWD

Download         Length: 231 bp

>AT100988 NZ_CP028339:378624-378854 [Thauera aromatica K172]
ATGCGTACCGTTGCGGTTGTCGAGGCCAAGAGCCAGTTTTCAGCGCTGTTGGCGGCAGTGGAGGGTGGCGAGGAGGTGGC
GATCACCCGGCGTGGGCGAGTCGTCGCTCGTCTGGTGCCGGATACGACGCGTTCGGCGGCGGATGTATTTCGGCCCTGCT
GGCAGGAAGGCGGGCTCGATCTGGCGGCGCCGGCCGATACGCCGGCCGAGCCGGTCGCCGGGTGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References