Detailed information of TA system TA100988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 378624..379262
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Tharo_RS01795
• Protein ID: WP_107219738.1
• Coordinates: 378861..379262 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: Tharo_RS01790
• Protein ID: WP_107219737.1
• Coordinates: 378624..378854 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS01775	375196..375519	+	324	WP_107219734.1	flagellar hook-basal body complex protein FliE	-
Tharo_RS01780	375671..376033	-	363	WP_107219735.1	flagellar protein FlaG	-
Tharo_RS01785	376092..378086	-	1995	WP_107219736.1	methyl-accepting chemotaxis protein	-
Tharo_RS01790	378624..378854	+	231	WP_107219737.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Tharo_RS01795	378861..379262	+	402	WP_107219738.1	PIN domain-containing protein	Toxin
Tharo_RS01800	379446..379580	-	135	WP_107219739.1	hypothetical protein	-
Tharo_RS01805	379708..380121	-	414	WP_107219740.1	helix-turn-helix domain-containing protein	-
Tharo_RS01810	380118..380405	-	288	WP_107219741.1	type II toxin-antitoxin system HigB family toxin	-
Tharo_RS01815	380789..381478	+	690	WP_107219742.1	DUF4325 domain-containing protein	-
Tharo_RS01820	381493..381729	-	237	WP_107219743.1	DUF1640 domain-containing protein	-
Tharo_RS01825	381867..382178	-	312	WP_107219744.1	helix-turn-helix domain-containing protein	-
Tharo_RS01830	382180..382476	-	297	WP_107219745.1	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-40)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14219.42 Da
• Isoelectric Point: 7.3207

>T100988 WP_107219738.1 NZ_CP028339:378861-379262 [Thauera aromatica K172]
MTHLLDTNIFIAALKAHPAVRARLESLPASAVVLSPIVLGELQTGVEKSEQVERNRARLEQVVAGLAVPRVDAATSAHYA
RIRAALERQGTPIGGNDLWIAAQALALGAVLVTDNVKEFSRVPGLVVENWLAQ

Nucleotide

• Length: 402 bp

>T100988 NZ_CP028339:378861-379262 [Thauera aromatica K172]
ATGACGCACCTGCTCGATACCAATATCTTCATCGCTGCGCTGAAGGCCCACCCGGCGGTTCGCGCGCGGCTCGAGTCCTT
GCCGGCCTCTGCAGTCGTTCTTTCGCCCATCGTCCTGGGCGAACTCCAGACCGGTGTGGAGAAGAGCGAACAGGTCGAGC
GTAACCGTGCACGGCTGGAGCAGGTGGTTGCGGGGCTTGCGGTGCCGCGGGTGGATGCCGCGACGAGCGCCCACTATGCA
CGGATCCGTGCCGCGCTCGAGCGGCAAGGCACGCCGATCGGTGGTAATGATCTCTGGATTGCGGCGCAGGCGCTTGCCCT
TGGTGCCGTGCTGGTCACCGATAACGTGAAGGAGTTCAGCCGCGTTCCGGGCCTGGTGGTGGAGAACTGGCTGGCTCAGT
GA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8007.05 Da
• Isoelectric Point: 4.4645

>AT100988 WP_107219737.1 NZ_CP028339:378624-378854 [Thauera aromatica K172]
MRTVAVVEAKSQFSALLAAVEGGEEVAITRRGRVVARLVPDTTRSAADVFRPCWQEGGLDLAAPADTPAEPVAGWD

Nucleotide

• Length: 231 bp

>AT100988 NZ_CP028339:378624-378854 [Thauera aromatica K172]
ATGCGTACCGTTGCGGTTGTCGAGGCCAAGAGCCAGTTTTCAGCGCTGTTGGCGGCAGTGGAGGGTGGCGAGGAGGTGGC
GATCACCCGGCGTGGGCGAGTCGTCGCTCGTCTGGTGCCGGATACGACGCGTTCGGCGGCGGATGTATTTCGGCCCTGCT
GGCAGGAAGGCGGGCTCGATCTGGCGGCGCCGGCCGATACGCCGGCCGAGCCGGTCGCCGGGTGGGATTGA