Detailed information of TA system TA100951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 7864..8389
• Replicon: plasmid pSC-09-1
• Accession: NZ_CP028319
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain CFSAN067216

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: C0X15_RS24700
• Protein ID: WP_001159863.1
• Coordinates: 7864..8169 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: C0X15_RS24705
• Protein ID: WP_000813641.1
• Coordinates: 8171..8389 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0X15_RS24660	3243..3803	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
C0X15_RS25390	3959..4246	+	288	WP_071530243.1	hypothetical protein	-
C0X15_RS24665	4523..5008	-	486	WP_000905606.1	membrane protein	-
C0X15_RS24670	5002..5511	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
C0X15_RS24680	5515..6228	-	714	Protein_9	EAL domain-containing protein	-
C0X15_RS24685	6237..7019	-	783	WP_000082169.1	site-specific integrase	-
C0X15_RS24690	7054..7575	-	522	WP_000198608.1	hypothetical protein	-
C0X15_RS24695	7572..7862	-	291	WP_001266176.1	hypothetical protein	-
C0X15_RS24700	7864..8169	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
C0X15_RS24705	8171..8389	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
C0X15_RS24710	9065..9586	+	522	WP_010999942.1	hypothetical protein	-
C0X15_RS24720	10070..10366	+	297	WP_001687482.1	hypothetical protein	-
C0X15_RS24725	10860..11849	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
C0X15_RS24730	12108..12552	-	445	Protein_18	site-specific integrase	-
C0X15_RS24735	12721..13102	-	382	Protein_19	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94045	94045

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-244)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T100951 WP_001159863.1 NZ_CP028319:c8169-7864 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T100951 NZ_CP028319:c8169-7864 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT100951 WP_000813641.1 NZ_CP028319:c8389-8171 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT100951 NZ_CP028319:c8389-8171 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6