Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 23150..23675 Replicon plasmid pSC-31-1
Accession NZ_CP028315
Organism Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain CFSAN067217

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag C7X12_RS24240 Protein ID WP_001159871.1
Coordinates 23370..23675 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag C7X12_RS24235 Protein ID WP_000813630.1
Coordinates 23150..23368 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7X12_RS24200 18151..18741 - 591 WP_000194550.1 hypothetical protein -
C7X12_RS24205 18741..18995 - 255 WP_000343103.1 hypothetical protein -
C7X12_RS24210 19347..20348 + 1002 WP_000774875.1 DUF4238 domain-containing protein -
C7X12_RS24215 20524..20868 - 345 WP_000793307.1 hypothetical protein -
C7X12_RS24220 21367..21621 - 255 WP_000678527.1 hypothetical protein -
C7X12_RS24225 21666..22592 - 927 WP_001290416.1 hypothetical protein -
C7X12_RS24235 23150..23368 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C7X12_RS24240 23370..23675 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
C7X12_RS24245 23676..24482 + 807 WP_000016969.1 site-specific integrase -
C7X12_RS24250 24662..25306 + 645 WP_001144036.1 ParA family protein -
C7X12_RS24255 25393..25701 + 309 WP_000030199.1 hypothetical protein -
C7X12_RS24260 26115..27095 + 981 WP_000688514.1 plasmid segregation protein ParM -
C7X12_RS24265 27088..27504 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..98989 98989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T100949 WP_001159871.1 NZ_CP028315:23370-23675 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T100949 NZ_CP028315:23370-23675 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT100949 WP_000813630.1 NZ_CP028315:23150-23368 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT100949 NZ_CP028315:23150-23368 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References