Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 5608..6155 Replicon plasmid pSC-31-1
Accession NZ_CP028315
Organism Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain CFSAN067217

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag C7X12_RS24115 Protein ID WP_000970007.1
Coordinates 5874..6155 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag C7X12_RS24110 Protein ID WP_000079941.1
Coordinates 5608..5877 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7X12_RS24065 1252..1785 - 534 WP_001303319.1 transcription termination factor NusG -
C7X12_RS24075 2227..2514 - 288 WP_000074849.1 conjugal transfer protein TraA -
C7X12_RS24080 2432..2695 - 264 WP_001324596.1 ash family protein -
C7X12_RS24095 3668..4699 + 1032 WP_000907873.1 replication initiation protein -
C7X12_RS24110 5608..5877 + 270 WP_000079941.1 hypothetical protein Antitoxin
C7X12_RS24115 5874..6155 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7X12_RS24120 6195..7043 + 849 WP_001057992.1 3'-5' exonuclease -
C7X12_RS24125 7160..7633 + 474 WP_001334658.1 hypothetical protein -
C7X12_RS26030 8110..8376 - 267 WP_000955263.1 hypothetical protein -
C7X12_RS24140 8376..8870 - 495 WP_001459505.1 hypothetical protein -
C7X12_RS24145 8926..9528 - 603 WP_000517695.1 hypothetical protein -
C7X12_RS24155 9882..10766 + 885 Protein_13 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..98989 98989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T100948 WP_000970007.1 NZ_CP028315:5874-6155 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T100948 NZ_CP028315:5874-6155 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT100948 WP_000079941.1 NZ_CP028315:5608-5877 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT100948 NZ_CP028315:5608-5877 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References