Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2566660..2567287 Replicon chromosome
Accession NZ_CP028273
Organism Mixta theicola strain SRCM103227

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag C7M52_RS11760 Protein ID WP_141177081.1
Coordinates 2567069..2567287 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag C7M52_RS11755 Protein ID WP_141177080.1
Coordinates 2566660..2567043 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M52_RS11740 2561985..2565134 + 3150 WP_141177077.1 efflux RND transporter permease subunit -
C7M52_RS11745 2565705..2566007 - 303 WP_160250595.1 hypothetical protein -
C7M52_RS11750 2566159..2566512 + 354 WP_141177079.1 hypothetical protein -
C7M52_RS11755 2566660..2567043 + 384 WP_141177080.1 Hha toxicity modulator TomB Antitoxin
C7M52_RS11760 2567069..2567287 + 219 WP_141177081.1 hemolysin expression modulator Hha Toxin
C7M52_RS11770 2567637..2567948 + 312 WP_160250596.1 MGMT family protein -
C7M52_RS11775 2567978..2568538 - 561 WP_141177082.1 YbaY family lipoprotein -
C7M52_RS11780 2568753..2569613 + 861 WP_141177083.1 acyl-CoA thioesterase II -
C7M52_RS11785 2569671..2570954 - 1284 WP_141177084.1 ammonium transporter AmtB -
C7M52_RS11790 2570988..2571326 - 339 WP_141177085.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.16 Da        Isoelectric Point: 8.9007

>T100930 WP_141177081.1 NZ_CP028273:2567069-2567287 [Mixta theicola]
MTEKLMTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 219 bp

>T100930 NZ_CP028273:2567069-2567287 [Mixta theicola]
ATGACAGAAAAACTTATGACTAAAACTGACTACCTGATGCGTTTAAGACGTTGCCGATCTATCGATACGCTTGAACGTGT
GATTGAAAAAAATAAGTATGAATTACCTGACGATGAGCTGGCAGTTTTTTATTCAGCCGCCGATCACCGTCTGGCTGAAT
TAACCATGAATAAGCTGTACGACAAAGTACCGGTTTCCGTGTGGAAATTTGTACGTTAG

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14824.43 Da        Isoelectric Point: 4.3024

>AT100930 WP_141177080.1 NZ_CP028273:2566660-2567043 [Mixta theicola]
MDEYSPKRHDIAQLNFLCENLYDESLATLGDSHHGWVNDPTSATNLQLNELIEHIASFTMNYKLKHAEDEDLIVQIDDYL
DDTFMLFSNYGINVQDLQRWQRSARRLFNLFAEECAQLPLQPSHSFS

Download         Length: 384 bp

>AT100930 NZ_CP028273:2566660-2567043 [Mixta theicola]
ATGGACGAATATTCACCGAAACGGCATGATATTGCCCAATTGAATTTCTTGTGTGAAAATCTGTACGATGAAAGTTTGGC
TACGCTGGGCGACAGCCATCATGGCTGGGTTAACGATCCTACCTCCGCGACCAACTTACAGCTGAATGAGCTTATTGAAC
ATATTGCTTCCTTCACCATGAATTATAAATTAAAGCATGCTGAAGACGAGGATCTCATCGTTCAGATTGATGATTACCTT
GACGATACTTTTATGTTGTTTAGTAATTACGGCATTAACGTTCAGGATCTACAGCGCTGGCAGCGCTCTGCCAGGCGTTT
GTTTAACCTTTTTGCTGAAGAATGTGCCCAGCTTCCTTTACAGCCAAGCCATTCGTTTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References