10093

Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type II Classification (family/domain) phd-doc/-
Location 1189587..1191349 Replicon chromosome
Accession NC_006351
Organism Burkholderia pseudomallei K96243

Toxin (Protein)


Gene name doc Uniprot ID Q63LW3
Locus tag BPS_RS23605 Protein ID WP_004556106.1
Coordinates 1189587..1190498 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag BPS_RS23610 Protein ID WP_004195450.1
Coordinates 1190495..1191349 (+) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPS_RS23575 (BPSS0893) 1184982..1186070 - 1089 WP_009939921.1 porin -
BPS_RS23580 (BPSS0894) 1186505..1186822 + 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
BPS_RS23585 (BPSS0895) 1186824..1187135 + 312 WP_004532856.1 hypothetical protein -
BPS_RS23590 (BPSS0896) 1187170..1188237 + 1068 WP_004551580.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BPS_RS23595 (BPSS0897) 1188234..1189004 + 771 WP_004524000.1 SDR family oxidoreductase -
BPS_RS23600 (BPSS0898) 1189043..1189570 + 528 WP_004524001.1 cupin domain-containing protein -
BPS_RS23605 (BPSS0899) 1189587..1190498 + 912 WP_004556106.1 alpha/beta fold hydrolase Toxin
BPS_RS23610 (BPSS0900) 1190495..1191349 + 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
BPS_RS23615 (BPSS0901) 1191346..1192143 + 798 WP_004528161.1 SDR family oxidoreductase -
BPS_RS23620 (BPSS0902) 1192136..1193809 + 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
BPS_RS23625 (BPSS0903) 1193802..1194617 + 816 WP_004551585.1 aspartate dehydrogenase -
BPS_RS23630 (BPSS0904) 1194643..1196133 + 1491 WP_009939933.1 aldehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(54-286)

Antitoxin

(143-265)


Sequences


Toxin        


Download         Length: 304 a.a.        Molecular weight: 30726.90 Da        Isoelectric Point: 8.4944

>T10093 WP_004556106.1 NC_006351:1189587-1190498 [Burkholderia pseudomallei K96243]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVAVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 912 bp

>T10093 NC_006351:1189587-1190498 [Burkholderia pseudomallei K96243]
ATGAGCACGATTTCCACGACGACAACCGAGGCGGGCGCGGCGCCGTTCGCCGCGCTGCTCGCACGCTTTCCCGAGCGGCG
CGCGGCGGTGGGCGGCGCCGGCGTGATCGGCTATCGCGAGGCGGGCGAAGCCCATGCGCGGCGCGCCGGATGCGAACCCG
TCGTGCTGCTGCACGGGATCGGCTCGGGGGCGGCGTCGTGGGTGCGCCAGCTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCACCCGGCTATGGCGCATCGTCGCGCGTCGCAGCCGATTCGCCCGTCGCGGCGGACTACGCGGCGTC
GCTCGCCGCGTGGCTCGACGCGCTGCGCATCGAGCGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCATGGCCGGCG
CGTTTGCACGAATCGCAGGCGAGCGGCTGGCGGGATTGCTGCTGATTTCCCCCGCGGGCGGCTACGGCAGCGCGCCCGCC
GACGTGCGGGCCGGGCGGCGCGACAGCCGCCTTGCGTTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCGAACATGCTGTCCGCGCAGGCGAGCGGCGCGGCGCGCGAGTGGGTGCGCTGGAACATGGCGCGCATCGCGCCCGCGG
GCTACGCGCAGGCGACGCATCTGCTCGCGAACGCGGATCTCGCCTCCGATCTTGCCCATTGCCGCGGCCGCATCGCGGTC
GCGGTCGCGGTCGGCGGCGACGATGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGCGGGCGGCGGGCGTCGGGCT
GCAGGTGATCGCGCGCGCGGGGCACGCCGGCTACGTCGAAGCGCCCGATGCATACAGCGCGTTGATCGACGCCTTTTGCC
GTCAATGCGACGGATCGCGAGGCACACCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT10093 WP_004195450.1 NC_006351:1190495-1191349 [Burkholderia pseudomallei K96243]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT10093 NC_006351:1190495-1191349 [Burkholderia pseudomallei K96243]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGAGGAATGATTCGAACTACGTCGTACCGGGGCTCGAGCGCGGGCT
GCGGATCCTGGCCGAGTTCTCGCCGCGAGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAAG
CCTGCGCGATGCGACGGGCTTCACCGCGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGAACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCGCAGTTGCGCGCGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGCGCTCTTCGACGTGATCCGCGACGATGCGCGGCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAAGCGAGCCGGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTCGTCGCCGAAGGGCTCGTCGAGAAGGTCGTGCGTGCGGCGGCCGAGCTGTCGCGGCGGCT
GAACTATCGGTCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q63LW3


Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References


(1) Brittany N Ross et al. (2020) Predicting toxins found in toxin-antitoxin systems with a role in host-induced Burkholderia pseudomallei persistence. Scientific Reports 10(1):16923. [PubMed:33037311] experimental


experimental experimental literature